Dose response and organ invasion of day-of-hatch leghorn chicks by different isolates of Campylobacter jejuni

被引:52
作者
Young, CR [1 ]
Ziprin, RL [1 ]
Hume, ME [1 ]
Stanker, LH [1 ]
机构
[1] USDA ARS, Food Anim Protect Res Lab, Food & Feed Safety Res Unit, College Stn, TX 77845 USA
关键词
Campylobacter jejuni; chickens; colonization;
D O I
10.2307/1592745
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Colonization of the ceca and organ invasion by different isolates of Campylobacter jejuni were investigated in day-of-hatch leghorn chicks. This model of Campylobacter colonization of the ceca demonstrates that I) day-of-hatch birds do not naturally contain cecal Campylobacter, 2) ceca can be colonized with C. jejuni by oral gavage and not by cloacal inoculation; 3) C. jejuni can be recovered from the ceca up until at least 7 days postinoculation, 4) cecal colonization occurs when as little as 10(2) colony-forming units is orally inoculated into chicks, and 5) different C. jejuni isolates vary both in their ability to colonize the ceca and in their ability to invade the liver. These studies demonstrate that we have a working animal model for Campylobacter colonization for day-of-hatch chicks. This animal model is being used to examine intervention strategies such as vaccines by which Campylobacter can be reduced or removed from the food animal.
引用
收藏
页码:763 / 767
页数:5
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