Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells

被引：134

作者：

Miranda, CL

Aponso, GLM

Stevens, JF

Deinzer, ML

Buhler, DR ^{[1
]}

机构：

[1] Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA

[2] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

CANCER LETTERS | 2000年 / 149卷 / 1-2期

关键词：

prenylflavonoids; chalcones; hops; quinone reductase; CYP1A1; hepa; 1c1c7;

D O I：

10.1016/S0304-3835(99)00328-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1A1 in this cell Line. In contrast, the synthetic chalcone, chalconaringenin, and the flavanone, naringenin, with no prenyl or geranyl groups, were ineffective in inducing QR. The hop chalcones, xanthohumol and dehydrocycloxanthohumol hydrate, also induced QR in the Ah-receptor-defective mutant cell line, Hepa 1c1c7 bp(r)c1. Thus, the prenylflavonoids represent a new class of monofunctional inducers of QR. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：21 / 29

页数：9

共 36 条

[1]

Bohm B. A, 1994, FLAVONOIDS ADV RES 1, P387

[2] Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the Phase II enzyme, quinone reductase [J].