Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial

被引：86

作者：

Cesari, Matteo ^{[1
,2
]}

Landi, Francesco ^{[3
]}

Calvani, Riccardo ^{[3
]}

Cherubini, Antonio ^{[4
]}

Di Bari, Mauro ^{[5
,6
]}

Kortebein, Patrick ^{[7
,8
,9
]}

Del Signore, Susanna ^{[10
]}

Le Lain, Regis ^{[11
]}

Vellas, Bruno ^{[1
,2
,12
]}

Pahor, Marco ^{[12
]}

Roubenoff, Ronenn ^{[13
]}

Bernabei, Roberto ^{[3
]}

Marzetti, Emanuele ^{[3
]}

机构：

[1] Ctr Hosp Univ Toulouse III, Gerontopole, 37 Allees Jules Guesde, F-31000 Toulouse, France

[2] Univ Toulouse III Paul Sabatier, Toulouse, France

[3] Catholic Univ, Sacred Heart Sch Med, Dept Geriatr Neurosci & Orthoped, Rome, Italy

[4] IRCCS INRCA, Geriatr & Geriatr Emergency Care, Ancona, Italy

[5] Univ Florence, Dept Expt & Clin Med, Res Unit Med Aging, Florence, Italy

[6] Azienda Osped Univ Careggi, Dept Geriatr & Med, Div Geriatr Cardiol & Med, Florence, Italy

[7] Sacramento VA Med Ctr, Phys Med & Rehabil Serv, Sacramento, CA USA

[8] Univ Calif Davis, Dept Phys Med & Rehabil, Sacramento, CA 95817 USA

[9] Novartis Inst Biomed Res, Cambridge, MA USA

[10] Bluecompan LTD, London, England

[11] Sanofi R&D, Chilly Mazarin, France

[12] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL USA

[13] Novartis Inst Biomed Res, Global Translat Med, Basel, Switzerland

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2017年 / 29卷 / 01期

关键词：

Physical function; Aging; Prevention; Skeletal muscle; Disability; LOWER-EXTREMITY FUNCTION; LIFE-STYLE INTERVENTIONS; WALK; 400; METERS; OLDER-ADULTS; MUSCLE MASS; GAIT SPEED; PERFORMANCE-MEASURES; SKELETAL-MUSCLE; HEALTH; DISABILITY;

D O I：

10.1007/s40520-016-0716-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

In the present article, the rationale that guided the operationalization of the theoretical concept of physical frailty and sarcopenia (PF&S), the condition of interest for the "Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies" (SPRINTT) trial, is presented. In particular, the decisions lead to the choice of the adopted instruments, and the reasons for setting the relevant thresholds are explained. In SPRINTT, the concept of physical frailty is translated with a Short Physical Performance Battery score of >= 3 and <= 9. Concurrently, sarcopenia is defined according to the recent definitions of low muscle mass proposed by the Foundation for the National Institutes of Health-Sarcopenia Project. Given the preventive purpose of SPRINTT, older persons with mobility disability (operationalized as incapacity to complete a 400-m walk test within 15 min; primary outcome of the trial) at the baseline are not included within the diagnostic spectrum of PF&S.

引用

页码：81 / 88

页数：8

共 46 条

[1]

Abizanda P, 2012, J FRALITY AGING, V1, P162, DOI 10.14283/jfa.2012.25

[2]

Grip Strength Cutpoints for the Identification of Clinically Relevant Weakness [J].

Alley, Dawn E. ;

Shardell, Michelle D. ;

Peters, Katherine W. ;

McLean, Robert R. ;

Dam, Thuy-Tien L. ;

Kenny, Anne M. ;

Fragala, Maren S. ;

Harris, Tamara B. ;

Kiel, Douglas P. ;

Guralnik, Jack M. ;

Ferrucci, Luigi ;

Kritchevsky, Stephen B. ;

Studenski, Stephanie A. ;

Vassileva, Maria T. ;

Cawthon, Peggy M. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2014, 69 (05) :559-566

[3]

Epidemiology of sarcopenia among the elderly in New Mexico [J].

Baumgartner, RN ;

Koehler, KM ;

Gallagher, D ;

Romero, L ;

Heymsfield, SB ;

Ross, RR ;

Garry, PJ ;

Lindeman, RD .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) :755-763

[4]

Cawthon PM, 2013, GERONTOLOGIST, V53, P594, DOI 10.1093/gerona/glu023

[5]

Sarcopenia and physical frailty: two sides of the same coin [J].

Cesari, Matteo ;

Landi, Francesco ;

Vellas, Bruno ;

Bernabei, Roberto ;

Marzetti, Emanuele .

FRONTIERS IN AGING NEUROSCIENCE, 2014, 6

[6]

Cesari M, 2014, EUR RESPIR J, V43, P1819, DOI 10.1183/09031936.00207913

[7]

The stress of aging [J].

Cesari, Matteo ;

Vellas, Bruno ;

Gambassi, Giovanni .

EXPERIMENTAL GERONTOLOGY, 2013, 48 (04) :451-456

[8]

Role of Gait Speed in the Assessment of Older Patients [J].

Cesari, Matteo .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (01) :93-94

[9]

Physical function and self-rated health status as predictors of mortality: Results from longitudinal analysis in the ilSIRENTE study [J].

Cesari M. ;

Onder G. ;

Zamboni V. ;

Manini T. ;

Shorr R.I. ;

Russo A. ;

Bernabei R. ;

Pahor M. ;

Landi F. .

BMC Geriatrics, 8 (1)

[10]

Added Value of Physical Performance Measures in Predicting Adverse Health-Related Events: Results from the Health, Aging and Body Composition Study [J].

Cesari, Matteo ;

Kritchevsky, Stephen B. ;

Newman, Anne B. ;

Simonsick, Eleanor M. ;

Harris, Tamara B. ;

Penninx, Brenda W. ;

Brach, Jennifer S. ;

Tylavsky, Frances A. ;

Satterfield, Suzanne ;

Bauer, Doug C. ;

Rubin, Susan M. ;

Visser, Marjolein ;

Pahor, Marco .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2009, 57 (02) :251-259

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