Survival-promoting functions of 14-3-3 proteins

被引：96

作者：

Masters, SC ^{[1
]}

Subramanian, RR ^{[1
]}

Truong, A ^{[1
]}

Yang, H ^{[1
]}

Fujii, K ^{[1
]}

Zhang, H ^{[1
]}

Fu, H ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2002年 / 30卷

关键词：

apoptosis; ASKI; Bad; difopein;

D O I：

10.1042/bst0300360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 14-3-3 proteins are a family of phosphoserine/phosphothreonine-binding molecules that control the function of a wide array of cellular proteins. We suggest that one function of 14-3-3 Is to support cell survival. 14-3-3 proteins promote survival in part by antagonizing the activity of associated proapoptotic proteins, including Bad and apoptosis signal-regulating kinase I (ASK1). Indeed, expression of 14-3-3 inhibitor peptides in cells is sufficient to induce apoptosis. Interestingly, these 14-3-3 antagonist peptides can sensitize cells for effective killing by anticancer agents such as cisplatin. Thus, 14-3-3 may be part of the cellular machinery that maintains cell survival, and targeting 14-3-3-ligand interactions may be a useful strategy to enhance the efficacy of conventional anticancer agents.

引用

页码：360 / 365

页数：6

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