In Vitro Anticancer Potential of Tree Extracts from the Walloon Region Forest

被引：34

作者：

Frederich, Michel ^{[1
]}

Marcowycz, Aline ^{[2
]}

Cieckiewicz, Ewa ^{[1
]}

Megalizzi, Veronique ^{[2
]}

Angenot, Luc ^{[1
]}

Kiss, Robert ^{[2
]}

机构：

[1] Univ Liege, Lab Pharmacognosy, CIRM, B-4000 Liege, Belgium

[2] Univ Libre Bruxelles, Toxicol Lab, Inst Pharm, Brussels, Belgium

来源：

PLANTA MEDICA | 2009年 / 75卷 / 15期

关键词：

cancer; Carpinus betulus; Quercus robur; Quercus petraea; Ilex aquifolium; Fagus sylvatica; STRUCTURAL-CHARACTERIZATION; CYTOTOXIC PROPERTIES; CASTANEA-SATIVA; 4-O-METHYLGLUCURONOXYLAN; APOPTOSIS; PLANTS; CELLS;

D O I：

10.1055/s-0029-1185867

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated for in vitro growth inhibitory activity against the human LoVo colon cancer, PC3 prostate cancer, and U373 glioblastoma cell lines. Our study was performed with the aim of selecting plant candidates in order to later isolate new anticancer compounds from an easily affordable tree material. Extracts from Alnus glutinosa (stem bark), Carpinus betulus (leaves and stem bark), Castanea sativa (stem bark), Fagus sylvatica (leaves), flex aquifolium (leaves), Larix decidua (leaves), Quercus petraea (stem bark), and Quercus robur (leaves) showed for the first time potent in vitro growth inhibitory activity and could become easily affordable sources of potential new anticancer agents. Root extracts from Robinia pseudoacacia, already known for containing cytotoxic lectins, also showed interesting activity.

引用

页码：1634 / 1637

页数：4

共 20 条

[1]

Structural characterization and cytotoxic properties of a 4-O-methylglucuronoxylan from Castanea sativa.: 2.: Evidence of a structure-activity relationship [J].

Barbat, Aline ;

Gloaguen, Vincent ;

Moine, Charlotte ;

Sainte-Catherine, Odile ;

Kraemer, Michel ;

Rogniaux, Helene ;

Ropartz, David ;

Krausz, Pierre .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (08) :1404-1409

[2]

Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay [J].

Bruggisser, R ;

von Daeniken, K ;

Jundt, G ;

Schaffner, W ;

Tullberg-Reinert, H .

PLANTA MEDICA, 2002, 68 (05) :445-448

[3]

Plants as a source of anti-cancer agents [J].

Cragg, GM ;

Newman, DJ .

JOURNAL OF ETHNOPHARMACOLOGY, 2005, 100 (1-2) :72-79

[4]

da Rocha Adriana B., 2001, Current Opinion in Pharmacology, V1, P364

[5]

New approach for the preparation of efficient DNA cleaving agents:: Ditopic copper-platinum complexes based on 3-clip-phen and cisplatin [J].

de Hoog, Paul ;

Boldron, Christophe ;

Gamez, Patrick ;

Sliedregt-Bol, Karen ;

Roland, Isabelle ;

Pitie, Marguerite ;

Kiss, Robert ;

Meunier, Bernard ;

Reedijk, Jan .

JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (13) :3148-3152

[6]

The amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts [J].

Dumont, Patrick ;

Ingrassia, Laurent ;

Rouzeau, Sebastien ;

Ribaucour, Fabrice ;

Thomas, Stephanie ;

Roland, Isabelle ;

Darro, Francis ;

Lefranc, Florence ;

Kiss, Robert .

NEOPLASIA, 2007, 9 (09) :766-776

[7]

Anticancer and antithrombin activity of Russian plants [J].

Goun, EA ;

Petrichenko, VM ;

Solodnikov, SU ;

Suhinina, TV ;

Kline, MA ;

Cunningham, G ;

Nguyen, C ;

Miles, H .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 81 (03) :337-342

[8]

Targeting autophagy: do patents reveal a therapeutic potential? [J].

Lefranc, Florence ;

Ingrassia, Laurent ;

Kiss, Robert .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2008, 18 (08) :813-819

[9]

Targeting the α1 subunit of the sodium pump to combat glioblastoma cells [J].

Lefranc, Florence ;

Mijatovic, Tatjana ;

Kondo, Yasuko ;

Sauvage, Sebastien ;

Roland, Isabelle ;

Debeir, Olivier ;

Krstic, Damjela ;

Vasic, Vesna ;

Gailly, Philippe ;

Kondo, Seiji ;

Blanco, Gustavo ;

Kiss, Robert .

NEUROSURGERY, 2008, 62 (01) :211-221

[10]

Proautophagic drugs: A novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas [J].

Lefranc, Florence ;

Facchini, Vincenzo ;

Kiss, Robert .

ONCOLOGIST, 2007, 12 (12) :1395-1403

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