Effect of fibrin glue on irradiated colonic anastomoses

被引：16

作者：

Karahasanoglu, T

Alcicek, S

Altunkaya, E

Sahinler, I

Goksel, S

Sirin, F

Ozbal, A

机构：

[1] ISTANBUL UNIV,CERRAHPASA MED SCH,DEPT RADIAT ONCOL,TR-34750 ISTANBUL,TURKEY

[2] ISTANBUL UNIV,CERRAHPASA MED SCH,DEPT PATHOL,TR-34750 ISTANBUL,TURKEY

来源：

DISEASES OF THE COLON & RECTUM | 1997年 / 40卷 / 10期

关键词：

preoperative irradiation; fibrin glue; colonic anastomoses;

D O I：

10.1007/BF02055171

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION: The present study was planned to research the effects of fibrin glue on irradiated colonic anastomoses. METHOD: The effect of fibrin glue on irradiated colonic anastomoses was investigated in four identical groups of rats. In Group I (control group) colonic anastomoses were performed without radiotherapy; in Group II, colonic anastomoses were performed five days after radiotherapy; in Group III, fibrin glue was applied to anastomotic line without radiotherapy; in Group IV, fibrin glue was applied to anastomotic line with radiotherapy. The healing of left colonic anastomoses was evaluated through the bursting pressure of the anastomotic segment and the hydroxyproline contents of the anastomosis. RESULTS: Measurements done on the fourth postoperative day revealed that anastomotic healing was impaired in rats that underwent radiotherapy (P < 0.001); fibrin glue had no effect on anastomotic heating in groups with or without radiotherapy. CONCLUSION: In the early phases of anastomotic healing, fibrin glue cannot help remove unwanted effects of preoperative radiotherapy.

引用

页码：1240 / 1243

页数：4

共 25 条

[1]

CROWLEY LG, 1968, ARCH SURG-CHICAGO, V96, P423

[2] THE EFFECTS OF PREOPERATIVE RADIATION ON HEALING OF RAT COLONIC ANASTOMOSES [J].

DEGGES, RD ;

CANNON, DJ ;

LANG, NP .

DISEASES OF THE COLON & RECTUM, 1983, 26 (09) :598-600

[3]

DEKKER E, 1962, J BIOL CHEM, V237, P2219

[4]

FRIEDMANN P, 1987, SURG GYNECOL OBSTET, V164, P257

[5]

GIARDINO R, 1986, GEN SURG ABDOMINAL S, P155

[6]

HOUSTON KA, 1988, ARCH SURG-CHICAGO, V123, P230

[7]

HULKKO OA, 1988, ACTA CHIR SCAND, V154, P49

[8]

LANGE EE, 1992, AM J RADIOL, V158, P287

[9] SUPPLEMENTAL VITAMIN-A PREVENTS THE ACUTE RADIATION-INDUCED DEFECT IN WOUND-HEALING [J].

LEVENSON, SM ;

GRUBER, CA ;

RETTURA, G ;

GRUBER, DK ;

DEMETRIOU, AA ;

SEIFTER, E .

ANNALS OF SURGERY, 1984, 200 (04) :494-512

[10] DOES PREOPERATIVE RADIATION-THERAPY ENHANCE THE PROBABILITY OF LOCAL-CONTROL AND SURVIVAL IN HIGH-RISK DISTAL RECTAL-CANCER [J].

MENDENHALL, WM ;

BLAND, KI ;

COPELAND, EM ;

SUMMERS, GE ;

PFAFF, WW ;

SOUBA, WW ;

MILLION, RR ;

MARTIN, RG ;

TOWNSEND, CM ;

HORSLEY, JS ;

HUMPHREY, LJ .

ANNALS OF SURGERY, 1992, 215 (06) :696-706

← 1 2 3 →