Nice Neighborhood: Emerging Concepts of the Stem Cell Niche

被引：263

作者：

Scadden, David T. ^{[1
,2
,3
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[2] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

CELL | 2014年 / 157卷 / 01期

关键词：

HEMATOPOIETIC STEM; BONE; REGENERATION; MAINTENANCE; SIGNALS; DEDIFFERENTIATION; RECONSTITUTION; LOCALIZATION; PROGENITORS; ENGRAFTMENT;

D O I：

10.1016/j.cell.2014.02.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

No metazoan cell survives on its own, absent the signals and support of its milieu. For multicellular life with specialized tissues to persist, organization is everything and so defining the association of position with cell state is critical to understanding how tissues function, maintain, and repair. This review focuses specifically on place for progenitor and stem cells. Especially emphasized are hematopoietic cells that balance free movement and stable position and where concepts of regulatory interrelationships have been shown with some precision. It reviews classical and emerging concepts of the niche, particularly considering how niche functions may participate in neoplastic disease.

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收藏

页码：41 / 50

页数：10

相关论文

共 71 条

[1] Heterologous cells cooperate to augment stem cell migration, homing, and engraftment [J].

Adams, GB ;

Chabner, KT ;

Foxall, RB ;

Weibrecht, KW ;

Rodrigues, NP ;

Dombkowski, D ;

Fallon, R ;

Poznansky, MC ;

Scadden, DT .

BLOOD, 2003, 101 (01) :45-51

[2]

ASH RC, 1991, BONE MARROW TRANSPL, V7, P443

[3] CYTOLOGICAL DEMONSTRATION OF CLONAL NATURE OF SPLEEN COLONIES DERIVED FROM TRANSPLANTED MOUSE MARROW CELLS [J].

BECKER, AJ ;

TILL, JE ;

MCCULLOCH, EA .

NATURE, 1963, 197 (486) :452-&

[4]

BERNSTEIN SE, 1959, P SOC EXP BIOL MED, V101, P769

[5] TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia [J].

Bhowmick, NA ;

Chytil, A ;

Plieth, D ;

Gorska, AE ;

Dumont, N ;

Shappell, S ;

Washington, MK ;

Neilson, EG ;

Moses, HL .

SCIENCE, 2004, 303 (5659) :848-851

[6] Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo [J].

Brawley, C ;

Matunis, E .

SCIENCE, 2004, 304 (5675) :1331-1334

[7] Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche [J].

Chow, Andrew ;

Lucas, Daniel ;

Hidalgo, Andres ;

Mendez-Ferrer, Simon ;

Hashimoto, Daigo ;

Scheiermann, Christoph ;

Battista, Michela ;

Leboeuf, Marylene ;

Prophete, Colette ;

van Rooijen, Nico ;

Tanaka, Masato ;

Merad, Miriam ;

Frenette, Paul S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :261-271

[8] Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells [J].

Colmone, Angela ;

Amorim, Maria ;

Pontier, Andrea L. ;

Wang, Sheng ;

Jablonski, Elizabeth ;

Sipkins, Dorothy A. .

SCIENCE, 2008, 322 (5909) :1861-1865

[9] COMPETITION, COMPETITIVE REPULSION, AND COEXISTENCE [J].

DARLINGTON, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (11) :3151-+

[10] CONDITIONS CONTROLLING PROLIFERATION OF HEMATOPOIETIC STEM-CELLS INVITRO [J].

DEXTER, TM ;

ALLEN, TD ;

LAJTHA, LG .

JOURNAL OF CELLULAR PHYSIOLOGY, 1977, 91 (03) :335-344

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