Little evidence for synergism among deleterious mutations in a nonsegmented RNA virus

被引:55
作者
Elena, SF
机构
[1] Univ Valencia, Inst Cavanilles Biodivers & Biol Evolut, Valencia 46071, Spain
[2] Univ Valencia, Dept Genet, Valencia 46071, Spain
关键词
deleterious mutations; epistasis; fitness; foot-and-mouth disease virus; genome segmentation;
D O I
10.1007/PL00000082
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several models have been proposed to account for the segmentation of RNA viruses. One of the best known models suggests that segmentation, and mixing of segments during coinfections, is a way to eliminate deleterious mutations from the genome. However, for validity, this model requires that deleterious mutations interact in a synergistic way. That is, two mutations together should have a more deleterious effect than the result of adding their individual effects. Here I present evidence that deleterious mutations in foot-and-mouth disease virus produce a decline in fitness but that the relationship between the number of mutations fixed and the magnitude of fitness decline is compatible mainly with a nonsynergistic model. However, the statistical uncertainties associated with the data still give some room for the existence of very weak synergistic epistasis.
引用
收藏
页码:703 / 707
页数:5
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