Secreted frizzled-related protein 4 (SFRP4) and fractalkine (CX3CL1) - Potential new biomarkers for β-cell dysfunction and diabetes

被引：33

作者：

Bergmann, Katarzyna ^{[1
]}

Sypniewska, Grazyna ^{[1
]}

机构：

[1] Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Lab Med, PL-85094 Bydgoszcz, Poland

来源：

CLINICAL BIOCHEMISTRY | 2014年 / 47卷 / 7-8期

关键词：

Diabetes; Insulin resistance; Adipocytokines; Secreted frizzled-related protein 4; Fractalkine; METABOLIC DYSFUNCTION; ACTIVATION; EXPRESSION; PATHWAYS; MELLITUS; CANCER; WNT10B;

D O I：

10.1016/j.clinbiochem.2014.03.007

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

The discovery of new risk factors for diabetes is a major challenge for contemporary science. Pathogenesis of type 2 diabetes mellitus (T2DM) is closely related to adipose tissue dysfunction. The aim of this review was to describe recently discovered cytokines: fractalkine (CX3CL1, FKN) and secreted frizzled-related protein 4 (SFRP4) as potential biomarkers of early beta cell dysfunction and diabetes. The association of CX3CL1 and SFRP4 with low-grade inflammation in adipose tissue links obesity with disturbances in insulin secretion and impaired glucose metabolism, therefore it indicates new therapeutic and preventive targets in both healthy and diabetic subjects. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：529 / 532

页数：4

共 36 条

[1]

Activation of Wnt/β-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells [J].

Abiola, Mounira ;

Favier, Maryline ;

Christodoulou-Vafeiadou, Eleni ;

Pichard, Anne-Lise ;

Martelly, Isabelle ;

Guillet-Deniau, Isabelle .

PLOS ONE, 2009, 4 (12)

[2]

[Anonymous], 2013, Diabetes Atlas, V6th edn

[3]

Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers? [J].

Bergmann, Katarzyna ;

Sypniewska, Grazyna .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2013, 51 (01) :177-185

[4]

Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells [J].

Carmon, Kendra S. ;

Loose, David S. .

MOLECULAR CANCER RESEARCH, 2008, 6 (06) :1017-1028

[5]

Fractalkine: A Cellular Link Between Adipose Tissue Inflammation and Vascular Pathologies [J].

Cefalu, William T. .

DIABETES, 2011, 60 (05) :1380-1382

[6]

High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells [J].

Dragomir, Elena ;

Manduteanu, Ileana ;

Calin, Manuela ;

Gan, Ana Maria ;

Stan, Daniela ;

Koenen, Rory Ryan ;

Weber, Christian ;

Simionescu, Maya .

THROMBOSIS AND HAEMOSTASIS, 2008, 100 (06) :1155-1165

[7]

Characterization of the Wnt Inhibitors Secreted Frizzled-Related Proteins (SFRPs) in Human Adipose Tissue [J].

Ehrlund, Anna ;

Mejhert, Niklas ;

Lorente-Cebrian, Silvia ;

Astrom, Gaby ;

Dahlman, Ingrid ;

Laurencikiene, Jurga ;

Ryden, Mikael .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (03) :E503-E508

[8]

High plasma fractalkine (CX3CL1) levels are associated with severe liver disease in HIV/HCV co-infected patients with HCV genotype 1 [J].

Garcia-Alvarez, Monica ;

Berenguer, Juan ;

Guzman-Fulgencio, Maria ;

Micheloud, Dariela ;

Catalan, Pilar ;

Angeles Munoz-Fernandez, Ma ;

Alvarez, Emilio ;

Resino, Salvador .

CYTOKINE, 2011, 54 (03) :244-248

[9]

From biomarkers to medical tests: The changing landscape of test evaluation [J].

Horvath, Andrea R. ;

Lord, Sarah J. ;

StJohn, Andrew ;

Sandberg, Sverre ;

Cobbaert, Christa M. ;

Lorenz, Stefan ;

Monaghan, Phillip J. ;

Verhagen-Kamerbeek, Wilma D. J. ;

Ebert, Christoph ;

Bossuyt, Patrick M. M. .

CLINICA CHIMICA ACTA, 2014, 427 :49-57

[10]

Mechanisms Behind the Anti-inflammatory Actions of Insulin [J].

Hyun, Eric ;

Ramachandran, Rithwik ;

Hollenberg, Morley D. ;

Vergnolle, Nathalie .

CRITICAL REVIEWS IN IMMUNOLOGY, 2011, 31 (04) :307-340

← 1 2 3 4 →