The two faces of BRCA2, a FANCtastic discovery

被引：33

作者：

Stewart, G

Elledge, SJ

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Howard Hughes Med Inst, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

MOLECULAR CELL | 2002年 / 10卷 / 01期

关键词：

D O I：

10.1016/S1097-2765(02)00580-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular defects responsible for the cancer predisposition syndrome Fanconi's Anemia (FA) have been elusive. A recent study reports that the FANC-B and -D1 subgroups result from hypomorphic mutations in BRCA2. Given that BRCA2 protein participates in homologous recombination, this finding connects at least a subset of the FA phenotypes to defective DNA repair.

引用

页码：2 / 4

页数：3

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