Subcellular localization of Nm23/NDPK A and B isoforms: a reflection of their biological function?

被引：36

作者：

Bosnar, Maja Herak ^{[1
]}

Bago, Ruzica ^{[1
]}

Cetkovic, Helena ^{[2
]}

机构：

[1] Rudjer Boskovic Inst, Div Mol Med, HR-10002 Zagreb, Croatia

[2] Rudjer Boskovic Inst, Div Mol Biol, HR-10002 Zagreb, Croatia

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2009年 / 329卷 / 1-2期

关键词：

Nm23; NDPK; Subcellular localization; Green fluorescent protein; Immunocytochemistry; NUCLEOSIDE DIPHOSPHATE KINASE; ASSEMBLY PROTEIN SET; TUMOR-METASTASIS; NUCLEAR-LOCALIZATION; CELL-ADHESION; NM23; GENES; SUPPRESSOR; EXPRESSION; IDENTIFICATION; PHOSPHORYLATION;

D O I：

10.1007/s11010-009-0107-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The family of Nm23/NDPK (nucleoside diphosphate kinase) proteins regulates a vast variety of cellular processes and, therefore, participates in important physiological events like proliferation, differentiation, molecular transport, and apoptosis. The majority of experimental data concerning this gene family has been focused on their engagement in metastasis formation--a critical point in tumor progression. In spite of the growing amount of evidence suggesting the multifunctional role of nm23/NDPKs the specific functions of every particular family member is still elusive. This review focuses on recent evidence on specific subcellular localization of Nm23-H1/NDPK A and Nm23-H2/NDPK B proteins and attempts to connect the findings to their diverse biological functions in the normal and/or malignantly transformed cell.

引用

页码：63 / 71

页数：9

共 77 条

[1]

Expression patterns of nm23 genes during mouse organogenesis [J].

Amrein, L ;

Barraud, P ;

Daniel, JY ;

Pérel, Y ;

Landry, M .

CELL AND TISSUE RESEARCH, 2005, 322 (03) :365-378

[2]

[Anonymous], 2000, The Development and Causes of Cancer. The cell: A Molecular Approach

[3]

Differential expression of nm23 genes in adult mouse dorsal root ganglia [J].

Barraud, P ;

Amrein, L ;

Dobremez, E ;

Dabernat, S ;

Masse, K ;

Larou, M ;

Daniel, JY ;

Landry, M .

JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 444 (04) :306-323

[4]

A DROSOPHILA GENE THAT IS HOMOLOGOUS TO A MAMMALIAN GENE ASSOCIATED WITH TUMOR-METASTASIS CODES FOR A NUCLEOSIDE DIPHOSPHATE KINASE [J].

BIGGS, J ;

HERSPERGER, E ;

STEEG, PS ;

LIOTTA, LA ;

SHEARN, A .

CELL, 1990, 63 (05) :933-940

[5]

Bosnar MH, 2008, CROAT CHEM ACTA, V81, P183

[6]

Subcellular localization of a and B Nm23/NDPK subunits [J].

Bosnar, MH ;

de Gunzburg, J ;

Bago, R ;

Brecevic, L ;

Weber, I ;

Pavelic, J .

EXPERIMENTAL CELL RESEARCH, 2004, 298 (01) :275-284

[7]

Caligo MA, 1997, INT J CANCER, V74, P102, DOI 10.1002/(SICI)1097-0215(19970220)74:1<102::AID-IJC18>3.0.CO

[8]

2-H

[9]

Bruton tyrosine kinase-like protein, BtkSD, is present sponge Suberites domuncula [J].

Cetkovic, H ;

Müller, WEG ;

Gamulin, V .

GENOMICS, 2004, 83 (04) :743-745

[10]

Ras-like small GTPases form a large family of proteins in the marine sponge Suberites domuncula [J].

Cetkovic, Helena ;

Mikoc, Andreja ;

Mueller, Werner E. G. ;

Gamulin, Vera .

JOURNAL OF MOLECULAR EVOLUTION, 2007, 64 (03) :332-341

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