Use of new antiepileptic drugs in the treatment of childhood epilepsy

被引：22

作者：

Pellock, JM

Appleton, R

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Div Child Neurol, Richmond, VA 23298 USA

[2] Alder Hey Childrens Hosp, Liverpool L12 2AP, Merseyside, England

来源：

EPILEPSIA | 1999年 / 40卷

关键词：

antiepileptic drugs; childhood epilepsy; pediatric epilepsy; refractory seizures; infantile spasms;

D O I：

10.1111/j.1528-1157.1999.tb00931.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The management of epilepsy in children requires careful evaluation, classification, and pharmacologic treatment. With classic antiepileptic drugs (AEDs), at least 25% of children remain refractory to appropriate therapy. The past decade has allowed the introduction of a number of newer AEDs for treatment of both adults and children with epilepsy. These include felbamate, gabapentin, lamotrigine, topiramate, tiagabine, and vigabatrin. Emerging information regarding the efficacy of these AEDs in treating childhood epilepsy syndromes suggests advantages for many patients. Limited data are available that define the optimal use of new AEDs in pediatric patients. Further research must be completed to validate the positive effects described in existing clinical trials of the new AEDs in the treatment of childhood epilepsy.

引用

页码：S29 / S38

页数：10

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