Notch1 control of oligodendrocyte differentiation in the spinal cord

被引：170

作者：

Genoud, S

Lappe-Siefke, C

Goebbels, S

Radtke, F

Aguet, M

Scherer, SS

Suter, U

Nave, KA

Mantei, N ^{[1
]}

机构：

[1] ETH Honggerberg, Swiss Fed Inst Technol, Dept Biol, Inst Cell Biol, CH-8093 Zurich, Switzerland

[2] Max Planck Inst Expt Med, Dept Neurogenet, D-37075 Gottingen, Germany

[3] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

[4] Univ Lausanne, Lausanne Branch, Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

[5] Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 158卷 / 04期

关键词：

ectopic expression; brain; Cre-lox P; newborn; apoptosis;

D O I：

10.1083/jcb.200202002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in the gray matter. At birth, OL apoptosis was strongly increased in Notch I mutant animals. Premature OL differentiation was also observed in the cerebrum, indicating that Notch1 is required for the correct spatial and temporal regulation of OL differentiation in various regions of the central nervous system. These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo.

引用

页码：709 / 718

页数：10

共 80 条

[1] Notch signalling controls pancreatic cell differentiation [J].