Chromatin conversations: Mechanisms and implications of paramutation

被引:152
作者
Chandler, VL
Stam, M
机构
[1] Univ Arizona, Dept Plant Sci, Tucson, AZ 85721 USA
[2] Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 SM Amsterdam, Netherlands
关键词
D O I
10.1038/nrg1378
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Paramutation is a widespread epigenetic phenomenon that was first described in pea and then extensively studied in maize, whereby combining two specific alleles results in a heritable change in the expression of one of the alleles. Far from being restricted to endogenous plant genes, paramutation-like interactions have been described in several kingdoms, in which they can occur between homologous transgenes or between transgenes and homologous endogenous genes at allelic or non-allelic positions. In this review, we discuss potential mechanisms underlying paramutation, compare paramutation to several other trans-sensing phenomena, and speculate on the potential roles and evolutionary implications of these intriguing homology-sensing mechanisms.
引用
收藏
页码:532 / 544
页数:13
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