Coronary heart disease and genetics: An epidemiologist's view

被引：19

作者：

Cambien, F ^{[1
]}

Poirier, O ^{[1
]}

Mallet, C ^{[1
]}

Tiret, L ^{[1
]}

机构：

[1] HOP BROUSSAIS,INSERM U258,F-75674 PARIS,FRANCE

来源：

MOLECULAR MEDICINE TODAY | 1997年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1357-4310(97)01027-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We are just beginning to uncover the genetic determinants of coronary heart disease. The genotype phenotype associations are complex as a consequence of pleiotropy, variation with age, selection owing to the high lethality of the disease, and interaction between genes and with environmental factors. Nevertheless, identification of the gene variants involved in the chronic and acute processes of coronary heart disease appears possible; this could considerably improve our understanding of the aetiology and mechanisms of this disease. Simultaneous analysis of several predisposing alleles should provide the means to identify high-risk individuals and to adapt therapeutic approaches to the genetic make-up of patients.

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收藏

页码：197 / 203

页数：7

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