Cell transplantation for stroke

被引：117

作者：

Savitz, SI

Rosenbaum, DM

Dinsmore, JH

Wechsler, LR

Caplan, LR

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA

[4] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USA

[5] Albert Einstein Coll Med, Dept Ophthalmol, Bronx, NY 10467 USA

[6] Diacrin Inc, Dept Cell Transplantat, Charlestown, MA USA

[7] Univ Pittsburgh, Med Ctr, Dept Neurol, Pittsburgh, PA USA

来源：

ANNALS OF NEUROLOGY | 2002年 / 52卷 / 03期

关键词：

D O I：

10.1002/ana.60000

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell tines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion.

引用

收藏

页码：266 / 275

页数：10

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