To be or NUCB2, is nesfatin the answer?

被引:40
作者
Cowley, Michael A. [1 ]
Grove, Kevin L. [1 ]
机构
[1] Oregon Hlth & Sci Univ, Div Neurosci, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA
关键词
D O I
10.1016/j.cmet.2006.11.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Signals from the hypothalamus govern food intake and energy balance. A new study describes nesfatin-1, a hypothalamic and brainstem peptide whose expression decreases during fasting. Although central treatment with nesfatin-1 inhibited food intake and nesfatin-1 blockade increased food intake, the role and mechanism of nesfatin in energy balance remains unclear.
引用
收藏
页码:421 / 422
页数:2
相关论文
共 8 条
[1]
A role for lateral hypothalamic orexin neurons in reward seeking [J].
Harris, GC ;
Wimmer, M ;
Aston-Jones, G .
NATURE, 2005, 437 (7058) :556-559
[2]
Identification of nesfatin-1 as a satiety molecule in the hypothalamus [J].
Oh-, Shinsuke, I ;
Shimizu, Hiroyuki ;
Satoh, Tetsurou ;
Okada, Shuichi ;
Adachi, Sachika ;
Inoue, Kinji ;
Eguchi, Hiroshi ;
Yamamoto, Masanori ;
Imaki, Toshihiro ;
Hashimoto, Koushi ;
Tsuchiya, Takafumi ;
Monden, Tsuyoshi ;
Horiguchi, Kazuhiko ;
Yamada, Masanobu ;
Mori, Masatomo .
NATURE, 2006, 443 (7112) :709-712
[3]
Antibodies as valuable neuroscience research tools versus reagents of mass distraction [J].
Rhodes, Kenneth J. ;
Trimmer, James S. .
JOURNAL OF NEUROSCIENCE, 2006, 26 (31) :8017-8020
[4]
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [J].
Sakurai, T ;
Amemiya, A ;
Ishii, M ;
Matsuzaki, I ;
Chemelli, RM ;
Tanaka, H ;
Williams, SC ;
Richardson, JA ;
Kozlowski, GP ;
Wilson, S ;
Arch, JRS ;
Buckingham, RE ;
Haynes, AC ;
Carr, SA ;
Annan, RS ;
McNulty, DE ;
Liu, WS ;
Terrett, JA ;
Elshourbagy, NA ;
Bergsma, DJ ;
Yanagisawa, M .
CELL, 1998, 92 (04) :573-585
[5]
Obestatin acts in brain to inhibit thirst [J].
Samson, Willis K. ;
White, Meghan M. ;
Price, Christopher ;
Ferguson, Alastair V. .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 292 (01) :R637-R643
[6]
Narcolepsy: A key role for hypocretins (orexins) [J].
Siegel, JM .
CELL, 1999, 98 (04) :409-412
[7]
Watts AG, 1999, PHYSIOL BEHAV, V65, P871
[8]
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J].
Zhang, JV ;
Ren, PG ;
Avsian-Kretchmer, O ;
Luo, CW ;
Rauch, R ;
Klein, C ;
Hsueh, AJW .
SCIENCE, 2005, 310 (5750) :996-999