Proteasome inhibition and Parkinson's disease modeling

被引:110
作者
Bove, Jordi
Zhou, Chun
Jackson-Lewis, Vernice
Taylor, Julie
Chu, Yaping
Rideout, Hardy J.
Wu, Du-Chu
Kordower, Jeffrey H.
Petrucelli, Leonard
Przedborski, Serge
机构
[1] Columbia Univ, Dept Neurol, New York, NY USA
[2] Mayo Clin Jacksonville, Coll Med, Jacksonville, FL 32224 USA
[3] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
[4] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA
[5] Columbia Univ, Ctr Neurobiol & Behav, New York, NY USA
关键词
D O I
10.1002/ana.20937
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Impaired proteasome function is a potential mechanism for dopaminergic neuron degeneration. To model this molecular defect, we administered systemically the reversible lipophilic proteasome inhibitor, carbobenzoxy-L-isoleucyl-gamma-t-butyl-Lglutamyl-L-alanyl-L-leucinal (PSI), to rodents. In contrast to a previous report, this approach failed to cause any detectable behavioral or neuropathological abnormality in either rats or mice. Although theoretically appealing, this specific model of Parkinson's disease appears to exhibit poor reproducibility.
引用
收藏
页码:260 / 264
页数:5
相关论文
共 20 条
  • [1] The proteasomal inhibition model of Parkinson's disease: "Boon or bust"?
    Beal, Flint
    Lang, Anthony
    [J]. ANNALS OF NEUROLOGY, 2006, 60 (02) : 158 - 161
  • [2] Impairment of the ubiquitin-proteasome system by protein aggregation
    Bence, NF
    Sampat, RM
    Kopito, RR
    [J]. SCIENCE, 2001, 292 (5521) : 1552 - 1555
  • [3] Chronic systemic pesticide exposure reproduces features of Parkinson's disease
    Betarbet, R
    Sherer, TB
    MacKenzie, G
    Garcia-Osuna, M
    Panov, AV
    Greenamyre, JT
    [J]. NATURE NEUROSCIENCE, 2000, 3 (12) : 1301 - 1306
  • [4] A vector for expressing foreign genes in the brains and hearts of transgenic mice
    Borchelt, DR
    Davis, J
    Fischer, M
    Lee, MK
    Slunt, HH
    Ratovitsky, T
    Regard, J
    Copeland, NG
    Jenkins, NA
    Sisodia, SS
    Price, DL
    [J]. GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 1996, 13 (06): : 159 - 163
  • [5] Braak H, 1995, J NEURAL TRANSM-SUPP, P15
  • [6] Parkinson's disease: Mechanisms and models
    Dauer, W
    Przedborski, S
    [J]. NEURON, 2003, 39 (06) : 889 - 909
  • [7] Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys
    Kordower, Jeffrey H.
    Kanaan, Nicholas M.
    Chu, Yaping
    Babu, Rangasamy Suresh
    Stansell, James, III
    Terpstra, Brian T.
    Sortwell, Caryl E.
    Steece-Collier, Kathy
    Collier, Timothy J.
    [J]. ANNALS OF NEUROLOGY, 2006, 60 (02) : 264 - 268
  • [8] Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Kostic, V
    JacksonLewis, V
    deBilbao, F
    DuboisDauphin, M
    Przedborski, S
    [J]. SCIENCE, 1997, 277 (5325) : 559 - 562
  • [9] Liberatore GT, 1999, NAT MED, V5, P1403
  • [10] Lack of nigrostriatal pathology in a rat model of proteasome inhibition
    Manning-Bog, Amy B.
    Reaney, Stephen H.
    Chou, Vivian P.
    Johnston, Louisa C.
    McCormack, Alison L.
    Johnston, Jennifer
    Langston, J. William
    Di Monte, Donato A.
    [J]. ANNALS OF NEUROLOGY, 2006, 60 (02) : 256 - 260