Molecular characterisation of In51, a class 1 integron containing a novel aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas aeruginosa

被引：29

作者：

Naas, T

Poirel, L

Nordmann, P

机构：

[1] Hop Bicetre, Assistance Publ Hopitaux Paris, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Hop Antoine Beclere, Assistance Publ Hopitaux Paris, Fac Med Paris Sud, Serv Bacteriol Virol, F-92141 Clamart, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1489卷 / 2-3期

关键词：

integron; aadA; aminoglycoside resistance; (Pseudomonas aeruginosa);

D O I：

10.1016/S0167-4781(99)00202-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polymerase chain reaction-amplification and subsequent sequencing of the variable region of a novel integron, In51, from Pseudomonas aeruginosa revealed the presence of a novel aminoglycoside adenylyltransferase gene, aadA6, together with an open reading frame of unknown function, orfD. AADA6 enzyme has only 75% amino acid identity with AADA1 and is able to confer high level resistance to streptomycin and spectinomycin in Escherichia coli. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：445 / 451

页数：7

共 24 条

[1] REVISED ANALYSIS OF AADA2 GENE OF PLASMID PSA [J].