Development by self-digestion: Molecular mechanisms and biological functions of autophagy

被引:3228
作者
Levine, B [1 ]
Klionsky, DJ
机构
[1] Columbia Univ, Dept Med, New York, NY 10032 USA
[2] Univ Michigan, Inst Life Sci, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Inst Life Sci, Dept Biol Chem, Ann Arbor, MI 48109 USA
关键词
D O I
10.1016/S1534-5807(04)00099-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Autophagy is the major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. It involves the rearrangement of subcellular membranes to sequester cargo for delivery to the lysosome where the sequestered material is degraded and recycled. For many decades, it has been known that autophagy occurs in a wide range of eukaryotic organisms and in multiple different cell types during starvation, cellular and tissue remodeling, and cell death. However, until recently, the functions of autophagy in normal development were largely unknown. The identification of a set of evolutionarily conserved genes that are essential for autophagy has opened up new frontiers for deciphering the role of autophagy in diverse biological processes. In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development.
引用
收藏
页码:463 / 477
页数:15
相关论文
共 110 条
  • [1] Abeliovich H, 2004, AUTOPHAGY, P60
  • [2] Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    Aita, VM
    Liang, XH
    Murty, VVVS
    Pincus, DL
    Yu, WP
    Cayanis, E
    Kalachikov, S
    Gilliam, TC
    Levine, B
    [J]. GENOMICS, 1999, 59 (01) : 59 - 65
  • [3] MUTANTS OF CAENORHABDITIS-ELEGANS THAT FORM DAUER-LIKE LARVAE
    ALBERT, PS
    RIDDLE, DL
    [J]. DEVELOPMENTAL BIOLOGY, 1988, 126 (02) : 270 - 293
  • [4] ROLE OF VACUOLAR APPARATUS IN AUGMENTED PROTEIN DEGRADATION IN CULTURED FIBROBLASTS
    AMENTA, JS
    SARGUS, MJ
    VENKATESAN, S
    SHINOZUKA, H
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1978, 94 (01) : 77 - 86
  • [5] The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    Arico, S
    Petiot, A
    Bauvy, C
    Dubbelhuis, PF
    Meijer, AJ
    Codogno, P
    Ogier-Denis, E
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) : 35243 - 35246
  • [6] Autophagic programmed cell death in Drosophila
    Baehrecke, EH
    [J]. CELL DEATH AND DIFFERENTIATION, 2003, 10 (09) : 940 - 945
  • [7] The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
    Bergamini, E
    Cavallini, G
    Donati, A
    Gori, Z
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2003, 57 (5-6) : 203 - 208
  • [8] Oncogenic kinase signalling
    Blume-Jensen, P
    Hunter, T
    [J]. NATURE, 2001, 411 (6835) : 355 - 365
  • [9] Ten years of protein kinase B signalling: a hard Akt to follow
    Brazil, DP
    Hemmings, BA
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (11) : 657 - 664
  • [10] Bursch W., 2004, AUTOPHAGY, P287