Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3

被引：13

作者：

Matsuda, S

Miyazaki, K

Ichigotani, Y

Kurata, H

Takenouchi, Y

Yamamoto, T

Nimura, Y

Irimura, T

Nakatsugawa, S

Hamaguchi, M

机构：

[1] Nagoya Univ, Sch Med, Dept Mol Pathogenesis, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Sch Med, Dept Surg 1, Showa Ku, Nagoya, Aichi 4668550, Japan

[3] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Canc Biol & Mol Immunol, Bunkyo Ku, Tokyo 1130033, Japan

[4] Nagoya Univ, Daiko Med Ctr, Div Radiol, Higashi Ku, Nagoya, Aichi 4610047, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2000年 / 1491卷 / 1-3期

关键词：

adapter protein; Src homology 3; leucine zipper; chromosome; 1q21-22; radiation hybrid mapping;

D O I：

10.1016/S0167-4781(00)00049-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1990 bp and has a predicted open reading frame encoding 433 amino acids. It possesses an Src homology 3 (SH3) motif, a leucine zipper motif and no catalytic domain, suggesting that it seems to be an adapter protein. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 1q21-22. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：321 / 326

页数：6

共 21 条

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2-0

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