A RHOse by any other name: a comparative analysis of animal and plant Rho GTPases

被引：57

作者：

Brembu, Tore

Winge, Per

Bones, Atle Magnar

Yang, Zhenbiao ^{[1
]}

机构：

[1] Univ Calif Riverside, Inst Integrat Genome Biol, Ctr Plant Cell Biol, Dept Bot & Plant Sci, Riverside, CA 92521 USA

[2] Norwegian Univ Sci & Technol, Dept Biol, N-7491 Trondheim, Norway

来源：

CELL RESEARCH | 2006年 / 16卷 / 05期

关键词：

Rho GTPase; RhoGAP; RhoGEF; RhoGDI; cytoskeleton; NADPH oxidase; RIC;

D O I：

10.1038/sj.cr.7310055

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho GTPases are molecular switches that act as key regulators of a many cellular processes, including cell movement, morphogenesis, host defense, cell division and gene expression. Rho GTPases are found in all eukaryotic kingdoms. Plants lack clear homologs to conventional Rho GTPases found in yeast and animals; instead, they have over time developed a unique subfamily, ROPs, also known as RAC. The origin of ROP-like proteins appears to precede the appearance of land plants. This review aims to discuss the evolution of ROP/RAC and to compare plant ROP and animal Rho GTPases, focusing on similarities and differences in regulation of the GTPases and their downstream effectors.

引用

收藏

页码：435 / 445

页数：11

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