Decreased density of lymphocyte benzodiazepine receptors in drug-resistant epileptic patients

被引：7

作者：

Ferrarese, C ^{[1
]}

Tortorella, R ^{[1
]}

Bogliun, G ^{[1
]}

Beghi, E ^{[1
]}

Cogliati, T ^{[1
]}

Zoia, C ^{[1
]}

Passoni, D ^{[1
]}

Frattola, L ^{[1
]}

机构：

[1] SCI INST EUGENIO MEDEA, Lecce, ITALY

来源：

EPILEPSY RESEARCH | 1997年 / 27卷 / 03期

关键词：

peripheral benzodiazepine receptors; epilepsy; anticonvulsant drugs; lymphocytes; drug resistance;

D O I：

10.1016/S0920-1211(97)01035-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Peripheral benzodiazepine receptors (PER) may have a role in epilepsy and in mediating antiepileptic drug effects. Since PER in blood mononuclear cells may be acted on by anticonvulsant drugs, we investigated possible modifications of these receptors in newly diagnosed patients, before and after antiepileptic treatment and in drug-resistant epileptic patients. A significantly lower receptor density, with no difference in affinity, was observed in drug-resistant patients, compared to newly diagnosed patients and to normal age-related controls. We suggest the possible use of PER as a peripheral marker of drug response. (C) 1997 Elsevier Science B.V.

引用

页码：181 / 185

页数：5

共 19 条

[1]

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