A novel approach to Finafloxacin hydrochloride (BAY35-3377)

被引：22

作者：

Hong, Jian ^{[1
]}

Zhang, Zonghua ^{[1
]}

Lei, Huoxing ^{[1
]}

Cheng, Haiying ^{[1
]}

Hu, Yufang ^{[1
]}

Yang, Wanliang ^{[1
]}

Liang, Yinglin ^{[1
]}

Das, Debasis ^{[1
]}

Chen, Shu-Hui ^{[1
]}

Li, Ge ^{[1
]}

机构：

[1] WuXi AppTec Inc, Shanghai 200131, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 21期

关键词：

Finafloxacin hydrochloride; BAY35-3377; Fluoroquinolone antibiotics; MYCOBACTERIUM-TUBERCULOSIS; QUINOLONE ANTIBACTERIALS; FLUOROQUINOLONES; DERIVATIVES; MECHANISM; DESIGN; AGENTS;

D O I：

10.1016/j.tetlet.2009.03.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Finafloxacin hydrochloride, an important clinical compound was synthesized by a novel synthetic approach. An active intermediate ethyl 7-chloro-8-cyano-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylate 19 was prepared by a new route. The chiral (S,S')-N-Boc 10 was derived from protected pyrrolidine and the absolute stereochemistry was established by X-ray analysis. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2525 / 2528

页数：4

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