Effects of estrogens only on the prostates of aging men

被引：34

作者：

vanKesteren, P

Meinhardt, W

vanderValk, P

Geldof, A

Megens, J

Gooren, L

机构：

[1] FREE UNIV AMSTERDAM HOSP, DEPT UROL, AMSTERDAM, NETHERLANDS

[2] FREE UNIV AMSTERDAM HOSP, DEPT PATHOL, AMSTERDAM, NETHERLANDS

[3] FREE UNIV AMSTERDAM HOSP, LAB EXPT ENDOCRINOL, AMSTERDAM, NETHERLANDS

来源：

JOURNAL OF UROLOGY | 1996年 / 156卷 / 04期

关键词：

orchiectomy; estrogens; prostate; aging;

D O I：

10.1016/S0022-5347(01)65584-8

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: The effects of estrogen only on prostate tissue were studied in 9 aging male transsexuals who had undergone orchiectomy. Materials and Methods: Prostate volume was measured by ultrasound. Biopsies were stained for prostatic acid phosphatase (PAP), prostate specific antigen (PSA), Ki-67 and sex steroid receptors. Results: Prostates were small, and biopsies showed PAP and PSA in most cases. No malignancy was found. Few androgen receptors were detectable but there were ample estrogen and progesterone receptors in stroma and epithelium. Conclusions: Prostates were small after long-term estrogens only. The sex steroid receptor content was considerably changed. PSA and PAP in the specimens suggested that their production does not depend on testicular androgens alone.

引用

收藏

页码：1349 / 1353

页数：5

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