Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol

被引：64

作者：

Basaraba, Randall J. ^{[1
]}

Smith, Erin E. ^{[1
]}

Shanley, Crystal A. ^{[1
]}

Orme, Ian M. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 09期

关键词：

EXPERIMENTAL AIRBORNE TUBERCULOSIS; CELL; LUNG; VACCINATION; NECROSIS;

D O I：

10.1128/IAI.00332-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.

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收藏

页码：5397 / 5401

页数：5

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