The role of the BAFF/APRIL system on T cell function

被引：146

作者：

Mackay, Fabienne ^{[1
]}

Leung, Helen ^{[1
]}

机构：

[1] Garvan Inst Med Res, Dept Immunol & Inflammat, Darlinghurst, NSW 2010, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2006年 / 18卷 / 05期

基金：

英国惠康基金;

关键词：

BAFF; BLyS; APRIL; T lymphocytes; autoimmunity; inflammation;

D O I：

10.1016/j.smim.2006.04.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BAFF is a key factor controlling B cell survival and maturation and its over-expression promotes B cell-mediated autoimmune disorders and participates in the progression of B cell lymphomas. Yet, BAFF and a related ligand APRIL are expressed by T lymphocytes and modulate their functions. BAFF and APRIL promote T cell activation and survival. BAFF over-expression in transgenic (Tg) mice enhances T helper 1 (Th1)-driven delayed-type hypersensitivity (DTH), but inhibits T helper 2 (Th2) cell-mediated allergic airway inflammation in mice. Some of these effects are also dependent on BAFF-induced modification of the B cell compartment. Therefore, direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：284 / 289

页数：6

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