Childhood acute renal failure: 22-year experience in a university hospital in southern Thailand

被引:104
作者
Vachvanichsanong, Prayong [1 ]
Dissaneewate, Pornsak
Lim, Apiradee
McNeil, Edward
机构
[1] Prince Songkla Univ, Fac Med, Dept Pediat, Hat Yai 90110, Thailand
[2] Prince Songkla Univ, Fac Med, Epidemiol Unit, Hat Yai 90110, Thailand
关键词
acute renal failure; renal replacement therapy; peritoneal dialysis;
D O I
10.1542/peds.2006-0557
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
OBJECTIVES. The objectives of this study were to review the prevalence, cause, and morbidity and mortality rates of acute renal failure in a large tertiary care institution in southern Thailand, to examine any differences in acute renal failure cases diagnosed during a 22-year period, and to determine the risk factors indicating death. METHODS. The case records for children 1 month to 17 years of age who were diagnosed as having acute renal failure between February 1982 and December 2004, in the Department of Pediatrics, Songklanagarind Hospital, in southern Thailand, were reviewed. RESULTS. A total of 311 children with 318 episodes of acute renal failure were included, that is, 177 boys (55.7%) and 141 girls (44.3%), 1 month to 16.7 years of age (mean age: 7.6 +/- 5.1 years; median age: 7.8 years). The causes of acute renal failure in each age group were significantly different. Overall, sepsis was the major cause of acute renal failure, accounting for 68 episodes (21.4%), followed by hypovolemia, poststreptococcal glomerulonephritis, systemic lupus erythematosus, and infectious diseases. Renal replacement therapy was performed in 55 cases (17.3%). The overall mortality rate was 41.5%. Logistic regression analysis showed that disease groups and creatinine levels were significant independent predictors of outcomes. CONCLUSIONS. The incidence of acute renal failure in Songklanagarind Hospital was 0.5 to 9.9 cases per 1000 pediatric patients, with a mortality rate of 41.5%. Sepsis was a major cause of acute renal failure and death. Causes of acute renal failure and serum creatinine levels were significant independent predictors of death.
引用
收藏
页码:E786 / E791
页数:6
相关论文
共 26 条
[1]  
Agarwal Indira, 2004, J Indian Med Assoc, V102, P353
[2]   Acute renal failure in the newborn [J].
Andreoli, SP .
SEMINARS IN PERINATOLOGY, 2004, 28 (02) :112-123
[3]   Acute renal failure in Nigerian children: Port Harcourt experience [J].
Anochie, IC ;
Eke, FU .
PEDIATRIC NEPHROLOGY, 2005, 20 (11) :1610-1614
[4]   Prognosis of acute renal failure in children: A multivariate analysis [J].
Arora, P ;
Kher, V ;
Rai, PK ;
Singhal, MK ;
Gulati, S ;
Gupta, A .
PEDIATRIC NEPHROLOGY, 1997, 11 (02) :153-155
[5]  
Barletta Gina-Marie, 2004, Curr Opin Crit Care, V10, P499, DOI 10.1097/01.ccx.0000144940.32521.de
[6]  
Boydstun Ivy I, 2005, Adolesc Med Clin, V16, P1, DOI 10.1016/j.admecli.2004.09.002
[7]   Molecular analysis of mutations and polymorphisms of the Lewis secretor type α(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation [J].
Chang, JG ;
Ko, YC ;
Lee, JCI ;
Chang, SJ ;
Liu, TC ;
Shih, MC ;
Peng, CT .
JOURNAL OF HUMAN GENETICS, 2002, 47 (02) :60-65
[8]  
Dobiliene Diana, 2005, Medicina (Kaunas), V41 Suppl 1, P21
[9]  
Flynn Joseph T., 1998, Current Opinion in Pediatrics, V10, P184, DOI 10.1097/00008480-199804000-00012
[10]   PROGNOSIS OF CHILDREN WITH ACUTE-RENAL-FAILURE - A STUDY OF 138 CASES [J].
GALLEGO, N ;
GALLEGO, A ;
PASCUAL, J ;
LIANO, F ;
ESTEPA, R ;
ORTUNO, J .
NEPHRON, 1993, 64 (03) :399-404