Pyrazole scaffold: A remarkable tool in the development of anticancer agents

被引：186

作者：

Kumar, Harish ^{[1
]}

Saini, Deepika ^{[1
]}

Jain, Sandeep ^{[1
]}

Jain, Neelam ^{[2
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Drug Discovery & Res Lab, Hisar 125001, Haryana, India

[2] Bhagat Phool Singh Mahila Vishwavidyalaya, Dept Pharmaceut Educ & Res, Sonepat 131305, Haryana, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 70卷

关键词：

Protein kinase inhibitor; Tyrosine kinase; Aurora-A kinase; Tumor growth factor (TGF); Cyclin dependent kinase (CDK); Antitubulin; DONOR MOIETY SYNTHESIS; BIOLOGICAL EVALUATION; SUBSTITUTED PYRAZOLES; ANTITUMOR-ACTIVITY; KINASE INHIBITORS; MOLECULAR DOCKING; LEAD OPTIMIZATION; DERIVATIVES; DESIGN; POTENT;

D O I：

10.1016/j.ejmech.2013.10.004

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Pyrazole has been the topic of interest for thousands of researchers across the world because of its wide spectrum pharmacological activities. Various structural modifications of the pyrazole nucleus have been made to explore its characteristics and biological potential. The present work aims to review the use of molecular modeling in the designing of novel pyrazole analogs that may target various receptors such as protein kinase inhibitor, tyrosine kinase, Aurora-A kinase, tumor growth factor (TGF), cyclin dependent kinase (CDK) and fibroblast growth factor (FGF), which are significant for the management of cancer. An insight has been given in this article for the importance of pyrazoles in the treatment of cancer and the perspectives that they hold for future research. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：248 / 258

页数：11

共 97 条

[1]

Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies [J].

Abdellatif, Khaled R. A. ;

Chowdhury, Morshed A. ;

Velazquez, Carlos A. ;

Huang, Zhangjian ;

Dong, Ying ;

Das, Dipankar ;

Yu, Gang ;

Suresh, Mavanur R. ;

Knaus, Edward E. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (15) :4544-4549

[2]

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies [J].

Abdellatif, Khaled R. A. ;

Chowdhury, Morshed Alam ;

Dong, Ying ;

Das, Dipankar ;

Yu, Gang ;

Velazquez, Carlos ;

Suresh, Mavanur R. ;

Knaus, Edward E. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (14) :5182-5188

[3]

Ahasan NusralBinta., 2007, J PHARM, V2, P81

[4]

Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors [J].

Akritopoulou-Zanze, Irim ;

Albert, Daniel H. ;

Bousquet, Peter F. ;

Cunha, George A. ;

Harris, Christopher M. ;

Moskey, Maria ;

Dinges, Jurgen ;

Stewart, Kent D. ;

Sowin, Thomas J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (11) :3136-3140

[5]

Differential estrogen receptor subtype modulators: Assessment of estrogen receptor subtype-bincling selectivity and transcription-regulating properties of new cycloalkyl pyrazoles [J].

Alexi, Xanthippi ;

Kasiotis, Konstantinos M. ;

Fokialakis, Nikolaos ;

Lambrinidis, George ;

Meligova, Aggeliki K. ;

Mikros, Emmanuel ;

Haroutounian, Serkos A. ;

Alexis, Michael N. .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2009, 117 (4-5) :159-167

[6]

Validated QSAR analysis of some diaryl substituted pyrazoles as CCR2 inhibitors by various linear and nonlinear multivariate chemometrics methods [J].

Arkan, Elham ;

Shahlaei, Mohsen ;

Pourhossein, Alireza ;

Fakhri, Kambiz ;

Fassihi, Afshin .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (08) :3394-3406

[7]

Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity [J].

Balbi, Alessandro ;

Anzaldi, Maria ;

Maccio, Chiara ;

Aiello, Cinzia ;

Mazzei, Mauro ;

Gangemi, Rosaria ;

Castagnola, Patrizio ;

Miele, Mariangela ;

Rosano, Camillo ;

Viale, Maurizio .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (11) :5293-5309

[8]

New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists [J].

Baraldi, PG ;

Tabrizi, MA ;

Preti, D ;

Bovero, A ;

Fruttarolo, F ;

Romagnoli, R ;

Zaid, NA ;

Moorman, AR ;

Varani, K ;

Borea, PA .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (15) :5001-5008

[9]

Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists [J].

Baraldi, PG ;

Tabrizi, MA ;

Preti, D ;

Bovero, A ;

Romagnoli, R ;

Fruttarolo, F ;

Zaid, NA ;

Moorman, AR ;

Varani, K ;

Gessi, S ;

Merighi, S ;

Borea, PA .

JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (06) :1434-1447

[10]

Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines [J].

Baraldi, PG ;

Pavani, MG ;

Nuñez, MD ;

Brigidi, P ;

Vitali, B ;

Gambari, R ;

Romagnoli, R .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (02) :449-456

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