Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation

被引：29

作者：

Chang, Hong

Yeung, Joanna

Xu, Wei

Ning, Yi

Patterson, Bruce

机构：

[1] Univ Toronto, Univ Hlth Network, Dept Lab Hematol, Toronto, ON, Canada

[2] Univ Toronto, Univ Hlth Network, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] Univ Maryland, Dept Cytogenet, Baltimore, MD 21201 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 134卷 / 06期

关键词：

plasma cell dyscrasia; CKS1B; fluorescence in situ hybridisation; tumour progression; monoclonal gammopathy of undetermined significance;

D O I：

10.1111/j.1365-2141.2006.06237.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The genetic events that lead to tumour progression in plasma cell dyscrasia are not well understood. Interphase cytoplasmic fluorescence in situ hybridisation was used to investigate the CKS1B amplification status (at 1q21) in clonal plasma cells from 123 patients: 23 monoclonal gammopathy of undetermined significance (MGUS), 75 multiple myeloma (MM) and 26 plasma cell leukaemia (PCL). While CKS1B amplification was absent in MGUS patients, such amplification (3-8 copies) was detected in 36% of newly diagnosed MM, 52% relapsed MM and 62% PCL (P < 0.001). Our results suggest that CKS1B amplification is associated with transformation from MGUS to MM and progression to PCL.

引用

页码：613 / 615

页数：3

共 13 条

[1] AvetLoiseau H, 1997, GENE CHROMOSOME CANC, V19, P124, DOI 10.1002/(SICI)1098-2264(199706)19:2<124::AID-GCC8>3.0.CO
[2] 2-0
[3] The absence of CD56 on malignant plasma cells in the cerebrospinal fluid is the hallmark of multiple myeloma involving central nervous system
Chang, H
Bartlett, ES
Patterson, B
Chen, CI
Yi, QL
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2005, 129 (04) : 539 - 541
[4] Genomic aberrations in plasma cell leukemia shown by interphase fluorescence in situ hybridization
Chang, H
Sloan, S
Li, D
Patterson, B
[J]. CANCER GENETICS AND CYTOGENETICS, 2005, 156 (02) : 150 - 153
[5] Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
Chang, H
Sloan, S
Li, D
Stewart, AK
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2004, 127 (03) : 280 - 284
[6] Genomic abnormalities in monoclonal gammopathy of undetermined significance
Fonseca, R
Bailey, RJ
Ahmann, GJ
Rajkumar, SV
Hoyer, JD
Lust, JA
Kyle, RA
Gertz, MA
Greipp, PR
Dewald, GW
[J]. BLOOD, 2002, 100 (04) : 1417 - 1424
[7] The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27
Ganoth, D
Bornstein, G
Ko, TK
Larsen, B
Tyers, M
Pagano, M
Hershko, A
[J]. NATURE CELL BIOLOGY, 2001, 3 (03) : 321 - 324
[8] Multiple myeloma: Evolving genetic events and host interactions
Kuehl, WM
Bergsagel, PL
[J]. NATURE REVIEWS CANCER, 2002, 2 (03) : 175 - 187
[9] A long-term study of prognosis in monoclonal gammopathy of undetermined significance
Kyle, RA
Therneau, TM
Rajkumar, SV
Offord, JR
Larson, DR
Plevak, MF
Melton, L
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (08) : 564 - 569
[10] Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors
Rasmussen, T
Kuehl, M
Lodahl, M
Johnsen, HE
Dahl, IMS
[J]. BLOOD, 2005, 105 (01) : 317 - 323

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