A minor groove binding track in reverse transcriptase

被引：111

作者：

Bebenek, K

Beard, WA

Darden, TA

Li, LP

Prasad, R

Luxon, BA

Gorenstein, DG

Wilson, SH

Kunkel, TA

机构：

[1] NIEHS, STRUCT BIOL LAB, RES TRIANGLE PK, NC 27709 USA

[2] NIEHS, LAB COMPUTAT BIOL & RISK ANAL, RES TRIANGLE PK, NC 27709 USA

[3] SEALY CTR MOL SCI, GALVESTON, TX 77555 USA

[4] UNIV TEXAS, MED BRANCH, SEALY CTR STRUCT BIOL, GALVESTON, TX 77555 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 03期

关键词：

D O I：

10.1038/nsb0397-194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence is presented indicating that processive synthesis by HIV-1 reverse transcriptase involves interactions between the minor groove of the template-primer and a discrete protein structural element, the minor groove binding track (MGBT).

引用

页码：194 / 197

页数：4

共 27 条

[1] Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta
Beard, WA
Osheroff, WP
Prasad, R
Sawaya, MR
Jaju, M
Wood, TG
Kraut, J
Kunkel, TA
Wilson, SH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) : 12141 - 12144
[2] Role of the ''helix clamp'' in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis
Beard, WA
Minnick, DT
Wade, CL
Prasad, R
Won, RL
Kumar, A
Kunkel, TA
Wilson, SH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) : 12213 - 12220
[3] BEARD WA, 1994, J BIOL CHEM, V269, P28091
[4] KINETIC-ANALYSIS OF TEMPLATE.PRIMER INTERACTIONS WITH RECOMBINANT FORMS OF HIV-1 REVERSE-TRANSCRIPTASE
BEARD, WA
WILSON, SH
[J]. BIOCHEMISTRY, 1993, 32 (37) : 9745 - 9753
[5] REDUCED FRAMESHIFT FIDELITY AND PROCESSIVITY OF HIV-1 REVERSE-TRANSCRIPTASE MUTANTS CONTAINING ALANINE SUBSTITUTIONS IN HELIX-H OF THE THUMB SUBDOMAIN
BEBENEK, K
BEARD, WA
CASASFINET, JR
KIM, HR
DARDEN, TA
WILSON, SH
KUNKEL, TA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (33) : 19516 - 19523
[6] Bebenek K, 1995, METHOD ENZYMOL, V262, P217
[7] STRUCTURE OF DNA-POLYMERASE-I KLENOW FRAGMENT BOUND TO DUPLEX DNA
BEESE, LS
DERBYSHIRE, V
STEITZ, TA
[J]. SCIENCE, 1993, 260 (5106) : 352 - 355
[8] SEROLOGICAL RELATIONSHIP BETWEEN REVERSE TRANSCRIPTASES FROM HUMAN T-CELL LYMPHOTROPIC VIRUSES DEFINED BY MONOCLONAL-ANTIBODIES - EVIDENCE FOR 2 FORMS OF REVERSE TRANSCRIPTASES IN THE AIDS-ASSOCIATED VIRUS, HTLV-III/LAV
CHANDRA, A
GERBER, T
KAUL, S
WOLF, C
DEMIRHAN, I
CHANDRA, P
[J]. FEBS LETTERS, 1986, 200 (02) : 327 - 332
[9] PROTEIN MOTIFS THAT RECOGNIZE STRUCTURAL FEATURES OF DNA
CHURCHILL, MEA
TRAVERS, AA
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1991, 16 (03) : 92 - 97
[10] PARTICLE MESH EWALD - AN N.LOG(N) METHOD FOR EWALD SUMS IN LARGE SYSTEMS
DARDEN, T
YORK, D
PEDERSEN, L
[J]. JOURNAL OF CHEMICAL PHYSICS, 1993, 98 (12) : 10089 - 10092

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