Expression of the microfilarial sheath protein 2 (shp2) of the filarial parasites Litomosoides sigmodontis and Brugia malayi

被引:6
作者
Conraths, FJ
Hirzmann, J
Hobom, G
Zahner, H
机构
[1] UNIV GIESSEN,INST PARASITOL,GIESSEN,GERMANY
[2] UNIV GIESSEN,INST MIKROBIOL & MOL BIOL,D-35392 GIESSEN,GERMANY
关键词
Litomosoides sigmodontis; Brugia malayi; filariasis; microfilariae; sheath; transcription;
D O I
10.1006/expr.1996.4138
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The microfilarial sheaths of the filarial parasites Brugia malayi, Brugia pahangi, and Litomosoides sigmodontis consist of several parasite proteins, probably ranging between 7 and 10. The gene encoding sheath protein 2 (shp2), which is the object of this study, is transcribed in embryos and in the uterine epithelium; at least in B. malayi, it is translated in both tissues. Apparently, shp2 is synthesized as a monomer, exported by the respective cells, and integrated into the microfilarial sheath. In the sheath, it exists as a highly polymerized molecule cross-linked by cysteine formation and other covalent bonds, presumably epsilon-(gamma-glutamyl)-lysine links. (C) 1997 Academic Press.
引用
收藏
页码:241 / 248
页数:8
相关论文
共 16 条
[1]   A MAJOR LITOMOSOIDES-CARINII MICROFILARIAL SHEATH GLYCOPROTEIN (GP22) - AMINO TERMINAL SEQUENCE AND IMMUNOLOGICAL STUDIES WITH CORRESPONDING SYNTHETIC PEPTIDES [J].
BARDEHLE, G ;
CONRATHS, FJ ;
FAHRENHOLZ, F ;
HINTZ, M ;
LINDER, D ;
SCHARES, G ;
SCHOTT, HH ;
SCHUTZLE, B ;
STIRM, S ;
STUBER, W ;
ZAHNER, H .
PARASITOLOGY, 1991, 103 :387-394
[2]   SEPARATION OF VIABLE MICROFILARIAE FREE OF BLOOD-CELLS ON PERCOLL GRADIENTS [J].
CHANDRASHEKAR, R ;
RAO, UR ;
RAJASEKARIAH, GR ;
SUBRAHMANYAM, D .
JOURNAL OF HELMINTHOLOGY, 1984, 58 (01) :69-70
[3]   TRANSSPLICING OF AN EARLY EMBRYO MESSENGER-RNA IN LITOMOSOIDES-CARINII, CODING FOR THE MAJOR MICROFILARIAL SHEATH PROTEIN GP22 [J].
CHRIST, H ;
HIRZMANN, J ;
CONRATHS, F ;
ZAHNER, H ;
STIRM, S ;
HOBOM, G .
GENE, 1992, 121 (02) :219-226
[4]   THE GENE CODING FOR THE MAJOR SHEATH PROTEIN OF LITOMOSOIDES-CARINII MICROFILARIAE, GP22, IS TRANSCRIBED IN OOCYTES AND EMBRYONIC-CELLS [J].
CONRATHS, FJ ;
SCHUTZLE, B ;
SCHARES, G ;
CHRIST, H ;
HOBOM, G ;
ZAHNER, H .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 60 (01) :111-120
[5]   TYROSINE-DERIVED CROSS-LINKING AMINO-ACIDS IN THE SHEATH OF HAEMONCHUS-CONTORTUS INFECTIVE LARVAE [J].
FETTERER, RH ;
RHOADS, ML .
JOURNAL OF PARASITOLOGY, 1990, 76 (05) :619-624
[6]  
FUJIMOTO D, 1981, BIOCHEM BIOPH RES CO, V99, P617
[7]   LITOMOSOIDES-CARINII MICROFILARIAL SHEATHS - PARTIAL AMINO-ACID-SEQUENCES OF SEVERAL MAJOR POLYPEPTIDE CONSTITUENTS [J].
HINTZ, M ;
HIRZMANN, J ;
HOBOM, G ;
LINDER, D ;
LOTTSPEICH, F ;
SCHOTT, HH ;
CONRATHS, FJ ;
ZAHNER, H ;
STIRM, S .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1994, 67 (01) :69-78
[8]   BRUGIA SPP AND LITOMOSOIDES-CARINII - IDENTIFICATION OF A COVALENTLY CROSS-LINKED MICROFILARIAL SHEATH MATRIX PROTEIN (SHP2) [J].
HIRZMANN, J ;
SCHNAUFER, A ;
HINTZ, M ;
CONRATHS, F ;
STIRM, S ;
ZAHNER, H ;
HOBOM, G .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 70 (1-2) :95-106
[9]   THE SHEATHS OF BRUGIA MICROFILARIAE - ISOLATION AND COMPOSITION [J].
KLONISCH, T ;
BARDEHLE, G ;
LINDER, D ;
BOSCHEK, B ;
SCHOTT, HH ;
ZAHNER, H ;
STIRM, S .
PARASITOLOGY RESEARCH, 1991, 77 (05) :448-451
[10]  
LAMMLER G, 1968, Zeitschrift fuer Parasitenkunde, V30, P281