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Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism

被引：101
作者：
Xia, Y
deSilva, HAR
Rosi, BL
Yamaoka, LH
Rimmler, JB
PericakVance, MA
Roses, AD
Chen, X
Masliah, E
DeTeresa, R
Iwai, A
Sundsmo, M
Thomas, RG
Hofstetter, CR
Gregory, E
Hansen, LA
Katzman, R
Thal, LJ
Saitoh, T
机构：
[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT NEUROSCI,LA JOLLA,CA 92093
[2] UNIV CALIF SAN DIEGO,SCH MED,DEPT FAMILY & PREVENT MED,LA JOLLA,CA 92093
[3] DUKE UNIV,MED CTR,JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR,DURHAM,NC
[4] CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM,LONDON W6 8RF,ENGLAND
来源：
ANNALS OF NEUROLOGY | 1996年 / 40卷 / 02期
关键词：
D O I：
10.1002/ana.410400212
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The non-A beta component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/alpha-synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.
引用
收藏
页码：207 / 215
页数：9
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