Surface modification of magnetite nanoparticles for biomedical applications

被引：49

作者：

Barrera, Carola ^{[1
]}

Herrera, Adriana ^{[1
]}

Zayas, Yashira ^{[1
]}

Rinaldi, Carlos ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem Engn, Puerto Rico Inst Funct Nanomat, Mayaguez, PR 00680 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

基金：

美国国家航空航天局; 美国国家科学基金会;

关键词：

Magnetite; Thermal decomposition; Carbodiimide; PEG; Dextran; FUNCTIONALIZATION;

D O I：

10.1016/j.jmmm.2009.02.046

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The preparation of magnetite nanoparticles with narrow size distributions using poly(ethylene glycol) (PEG-COOH) or carboxymethyl dextran (CMDx) chains covalently attached to the particle surface using carbodiimide chemistry is described. Particles were synthesized by thermal decomposition and modified with 3-aminopropyl trimethoxysilane (APS) to render particles with reactive amine groups (-NH2) on their surface. Amines were then reacted with carboxyl groups in PEG-COOH or CMDx using carbodiimide chemistry in water. The size and stability of the functionalized magnetic nanoparticles was studied as a function of pH and ionic strength using dynamic light scattering and zeta potential measurements. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1397 / 1399

页数：3

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