IL-27, a heterodimeric cytokine composed of EB13 and p28 protein, induces proliferation of naive CD4+ T cells

被引：1163

作者：

Pflanz, S ^{[1
]}

Timans, JC ^{[1
]}

Cheung, J ^{[1
]}

Rosales, R ^{[1
]}

Kanzler, H ^{[1
]}

Gilbert, J ^{[1
]}

Hibbert, L ^{[1
]}

Churakova, T ^{[1
]}

Travis, M ^{[1
]}

Vaisberg, E ^{[1
]}

Blumenschein, WM ^{[1
]}

Mattson, JD ^{[1
]}

Wagner, JL ^{[1
]}

To, W ^{[1
]}

Zurawski, S ^{[1
]}

McClanahan, TK ^{[1
]}

Gorman, DM ^{[1
]}

Bazan, JF ^{[1
]}

Malefyt, RD ^{[1
]}

Rennick, D ^{[1
]}

Kastelein, RA ^{[1
]}

机构：

[1] DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA

来源：

IMMUNITY | 2002年 / 16卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(02)00324-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.

引用

页码：779 / 790

页数：12

共 31 条

[1] Construction and biological characterization of an interleukin-12 fusion protein (Flexi-12): Delivery to acute myeloid leukemic blasts using adeno-associated virus
Anderson, R
MacDonald, I
Corbet, T
Hacking, G
Lowdell, MW
Prentice, HG
[J]. HUMAN GENE THERAPY, 1997, 8 (09) : 1125 - 1135
[2] HEMATOPOIETIC RECEPTORS AND HELICAL CYTOKINES
BAZAN, JF
[J]. IMMUNOLOGY TODAY, 1990, 11 (10): : 350 - 354
[3] Bolin LM, 1997, J NEUROSCI, V17, P5493
[4] Development of Th1-type immune responses requires the type I cytokine receptor TCCR
Chen, Q
Ghilardi, N
Wang, H
Baker, T
Xie, MH
Gurney, A
Grewal, IS
de Sauvage, FJ
[J]. NATURE, 2000, 407 (6806) : 916 - 920
[5] David ZV, 1998, E EUR POLIT SOC, V12, P1
[6] A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes
Devergne, O
Hummel, M
Koeppen, H
LeBeau, MM
Nathanson, EC
Kieff, E
Birkenbach, M
[J]. JOURNAL OF VIROLOGY, 1996, 70 (02) : 1143 - 1153
[7] Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
Devergne, O
Birkenbach, M
Kieff, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) : 12041 - 12046
[8] Expression of Epstein-Barrvirus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy -: Involvement of syncytiotrophoblasts and extravillous trophoblasts
Devergne, O
Coulomb-L'Herminé, A
Capel, F
Moussa, M
Capron, F
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (05) : 1763 - 1776
[9] CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
Elson, GCA
Lelièvre, E
Guillet, C
Chevalier, S
Plun-Favreau, H
Froger, J
Suard, I
de Coignac, AB
Delneste, Y
Bonnefoy, JY
Gauchat, JF
Gascan, H
[J]. NATURE NEUROSCIENCE, 2000, 3 (09) : 867 - 872
[10] FISCHER M, 1997, NAT BIOTECHNOL, V69, P139

← 1 2 3 4 →