Tubby-like protein 1 as an autoantigen in cancer-associated retinopathy

被引：42

作者：

Kikuchi, T

Arai, J

Shibuki, H

Kawashima, H

Yoshimura, N ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Ophthalmol, Matsumoto, Nagano 3908621, Japan

[2] Jichi Med Sch, Dept Ophthalmol, Minami Kawachi, Tochigi 32904, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 103卷 / 01期

关键词：

cancer-associated retinopathy; paraneoplastic syndrome; retinal degeneration; autoantibodies; tubby-like protein 1; endometrial cancer;

D O I：

10.1016/S0165-5728(99)00163-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome that is characterized by retinal degeneration. Two cDNA clones, recoverin and tubby-like protein 1 (TULP1), were isolated from a human retinal cDNA library by using serum from a CAR patient as the probe. Both recoverin and TULP1 are retina-specific protein, and TULP1 is a member of tubby gene family. A determination of the recognized amino acid sequence of TULP1 by the patient serum and immunohistochemical studies on the distribution of TULP1 in the retina were done in this study. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：26 / 33

页数：8

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