Subdiaphragmatic vagal deafferentation fails to block the anorectic effect of hydroxycitrate

被引：9

作者：

Leonhardt, M ^{[1
]}

Hrupka, BJ ^{[1
]}

Langhans, W ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Inst Anim Sci, CH-8603 Schwerzenbach, Switzerland

来源：

PHYSIOLOGY & BEHAVIOR | 2004年 / 82卷 / 2-3期

关键词：

food intake; afferent nerves; fatty acid synthesis; rats;

D O I：

10.1016/j.physbeh.2004.03.021

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

We investigated the neural mediation of the feeding suppression through orally administered hydroxycitrate (HCA) in male rats that were fed a high-glucose diet (about 48% glucose). Ten-day ad libitum food intake and body weight regain after previous body weight loss (13% of initial body weight) due to restrictive feeding were measured in rats with sham deafferentation (SHAM; n = 6), subdiaphragmatic vagal deafferentation (SDA; n = 7), and SDA plus celiac-superior mesenteric ganglionectomy (SDA/CGX; n = 9). HCA suppressed the 10-day cumulative food intake in all surgical groups and body weight regain in SDA and SDA/CGX groups. Independent of HCA, SDA and SDA/ CGX rats consumed less food and gained less weight compared to SHAM rats. These results demonstrate that all vagal afferents from below the diaphragm and vagal efferents of the dorsal trunk as well as splanchnic nerves (afferents and efferents) are not necessary for the feeding-suppressive effect of HCA in this animal model. Vagal afferents, however, appear to play a role in the control of intake when a high-glucose diet is consumed after a period of restrictive feeding. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：263 / 268

页数：6

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