SAM-T08, HMM-based protein structure prediction

被引:103
作者
Karplus, Kevin [1 ]
机构
[1] Univ Calif Santa Cruz, Dept Biomol Engn, Baskin Sch Engn, Santa Cruz, CA 95064 USA
基金
美国国家卫生研究院;
关键词
MODEL QUALITY ASSESSMENT; HIDDEN MARKOV-MODELS; LOCAL-STRUCTURE; FOLD-RECOGNITION; INFORMATION; ALPHABETS;
D O I
10.1093/nar/gkp403
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The SAM-T08 web server is a protein structure prediction server that provides several useful intermediate results in addition to the final predicted 3D structure: three multiple sequence alignments of putative homologs using different iterated search procedures, prediction of local structure features including various backbone and burial properties, calibrated E-values for the significance of template searches of PDB and residue-residue contact predictions. The server has been validated as part of the CASP8 assessment of structure prediction as having good performance across all classes of predictions. The SAM-T08 server is available at http://compbio.soe.ucsc.edu/SAM_T08/T08-query.html
引用
收藏
页码:W492 / W497
页数:6
相关论文
共 25 条
  • [1] BASIC LOCAL ALIGNMENT SEARCH TOOL
    ALTSCHUL, SF
    GISH, W
    MILLER, W
    MYERS, EW
    LIPMAN, DJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
  • [2] Applying undertaker cost functions to model quality assessment
    Archie, John
    Karplus, Kevin
    [J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2009, 75 (03) : 550 - 555
  • [3] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES
    BERNSTEIN, FC
    KOETZLE, TF
    WILLIAMS, GJB
    MEYER, EF
    BRICE, MD
    RODGERS, JR
    KENNARD, O
    SHIMANOUCHI, T
    TASUMI, M
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1977, 112 (03) : 535 - 542
  • [4] HMMSTR: a hidden Markov model for local sequence-structure correlations in proteins
    Bystroff, C
    Thorsson, V
    Baker, D
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2000, 301 (01) : 173 - 190
  • [5] de Brevern AG, 2000, PROTEINS, V41, P271, DOI 10.1002/1097-0134(20001115)41:3<271::AID-PROT10>3.0.CO
  • [6] 2-Z
  • [7] Fischer D, 1999, PROTEINS, P209
  • [8] Proteopedia -: a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules
    Hodis, Eran
    Prilusky, Jaime
    Martz, Eric
    Silman, Israel
    Moult, John
    Sussman, Joel L.
    [J]. GENOME BIOLOGY, 2008, 9 (08)
  • [9] Hughey R, 1996, COMPUT APPL BIOSCI, V12, P95
  • [10] HUGHEY R, 1999, UCSCCRL9911 COMP ENG