Ranolazine and late cardiac sodium current - a therapeutic target for angina, arrhythmia and more?

被引：23

作者：

Makielski, JC ^{[1
]}

Valdivia, CR ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med, Cardiovasc Med Sect, Madison, WI 53792 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2006年 / 148卷 / 01期

关键词：

I-Na; sodium current; I-NaL; late sodium current;

D O I：

10.1038/sj.bjp.0706713

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ranolazine is a new antianginal drug approved for clinical use in the United States in January 2006. A study published in this same issue of the British Journal of Pharmacology characterizes ranolazine block of late sodium current caused by the long QT syndrome 3 mutations. This commentary discusses the implications of that study and the background and implications for block of late cardiac sodium current in general.

引用

页码：4 / 6

页数：3

共 25 条

[1]

ANERSON SE, 1990, AM J PHYSIOL, V259, pC940

[2] Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties [J].

Antzelevitch, C ;

Belardinelli, L ;

Zygmunt, AC ;

Burashnikov, A ;

Di Diego, JM ;

Fish, JM ;

Cordeiro, JM ;

Thomas, G .

CIRCULATION, 2004, 110 (08) :904-910

[3]

BELARDINELLI L, 2004, EUR HEART J SUPPL, V6, P13

[4] EFFECT OF RANOLAZINE ON INFARCT SIZE IN A CANINE MODEL OF REGIONAL MYOCARDIAL ISCHEMIA/REPERFUSION [J].

BLACK, SC ;

GRALINSKI, MR ;

MCCORMACK, JG ;

DRISCOLL, EM ;

LUCCHESI, BR .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1994, 24 (06) :921-928

[5] Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina [J].

Chaitman, BR ;

Skettino, SL ;

Parker, JO ;

Hanley, P ;

Meluzin, J ;

Kuch, J ;

Pepine, CJ ;

Wang, W ;

Nelson, JJ ;

Hebert, DA ;

Wolff, AA .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (08) :1375-1382

[6] Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina - A randomized controlled trial [J].

Chaitman, BR ;

Pepine, CJ ;

Parker, JO ;

Skopal, J ;

Chumakova, G ;

Kuch, J ;

Wang, WD ;

Skettino, SL ;

Wolff, AA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (03) :309-316

[7] Multiple mechanisms of Na+ channel-linked long-QT syndrome [J].

Dumaine, R ;

Wang, Q ;

Keating, MT ;

Hartmann, HA ;

Schwartz, PJ ;

Brown, AM ;

Kirsch, GE .

CIRCULATION RESEARCH, 1996, 78 (05) :916-924

[8] Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action [J].

Fredj, Sandra ;

Sampson, Kevin J. ;

Liu, Huajun ;

Kass, Robert S. .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 148 (01) :16-24

[9] CARDIOPROTECTIVE EFFECTS OF RANOLAZINE (RS-43285) IN THE ISOLATED-PERFUSED RABBIT HEART [J].

GRALINSKI, MR ;

BLACK, SC ;

KILGORE, KS ;

CHOU, AY ;

MCCORMACK, JG ;

LUCCHESI, BR .

CARDIOVASCULAR RESEARCH, 1994, 28 (08) :1231-1237

[10] SYMPOSIUM ON PERSPECTIVES ON THE TREATMENT OF VENTRICULAR ARRHYTHMIAS - INTRODUCTION [J].

HARRISON, DC .

AMERICAN JOURNAL OF CARDIOLOGY, 1983, 52 (06) :C1-C2

← 1 2 3 →