Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation

被引:58
作者
Anthwal, Amit [1 ]
Thakur, Bandana K. [1 ]
Rawat, M. S. M. [1 ]
Rawat, D. S. [2 ]
Tyagi, Amit K. [3 ,4 ]
Aggarwal, Bharat B. [3 ,4 ]
机构
[1] HNB Garhwal Univ, Dept Chem, Srinagar 246174, Uttarakhand, India
[2] Univ Delhi, Dept Chem, Delhi 110007, India
[3] Univ Texas MD Anderson Canc Ctr, Cytokine Res Lab, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, Pharmaceut Dev Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
关键词
CANCER; ANGIOGENESIS; METABOLISM; OXIDATION; LIVER;
D O I
10.1155/2014/524161
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out. The new compounds demonstrated good cytotoxicity against chronic myeloid leukemia (KBM5) and colon cancer (HCT116) cell lines. Further, these compounds were found to have better potential to inhibit TNF-alpha-induced NF-kappa B activation in comparison to curcumin, which show their potential to act as anti-inflammatory agents. Some compounds were found to show higher cytotoxicity against cancer cell lines in comparison to curcumin used as standard.
引用
收藏
页数:10
相关论文
共 34 条
[1]  
Aggarwal BB, 2003, ANTICANCER RES, V23, P363
[2]   Potential of Spice-Derived Phytochemicals for Cancer Prevention [J].
Aggarwal, Bharat B. ;
Kunnumakkara, Ajaikumar B. ;
Harikumar, Kuzhuvelil B. ;
Tharakan, Sheeja T. ;
Sung, Bokyung ;
Anand, Preetha .
PLANTA MEDICA, 2008, 74 (13) :1560-1569
[3]   Curcumin and cancer: An "old-age" disease with an "age-old" solution [J].
Anand, Preetha ;
Sundaram, Chitra ;
Jhurani, Sonia ;
Kunnumakkara, Ajaikumar B. ;
Aggarwal, Bharat B. .
CANCER LETTERS, 2008, 267 (01) :133-164
[4]   Novel metronidazole-chalcone conjugates with potential to counter drug resistance in Trichomonas vaginalis [J].
Anthwal, Amit ;
Rajesh, U. Chinna ;
Rawat, M. S. M. ;
Kushwaha, Bhavana ;
Maikhuri, Jagdamba P. ;
Sharma, Vishnu L. ;
Gupta, Gopal ;
Rawat, Diwan S. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 79 :89-94
[5]   Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue [J].
Asai, A ;
Miyazawa, T .
JOURNAL OF NUTRITION, 2001, 131 (11) :2932-2935
[6]   2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists [J].
Chang, LCW ;
Spanjersberg, RF ;
Künzel, JKV ;
Mulder-Krieger, T ;
van den Hout, G ;
Beukers, MW ;
Brussee, J ;
IJzerman, AP .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (26) :6529-6540
[7]  
Chaturvedi MM, 2000, METHOD ENZYMOL, V319, P585
[8]   Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption [J].
Clark, DE .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 88 (08) :807-814
[9]   Natural products in drug discovery and development [J].
Cragg, GM ;
Newman, DJ ;
Snader, KM .
JOURNAL OF NATURAL PRODUCTS, 1997, 60 (01) :52-60
[10]   Curcumin as "Curecumin":: From kitchen to clinic [J].
Goel, Ajay ;
Kunnumakkara, Ajaikumar B. ;
Aggarwal, Bharat B. .
BIOCHEMICAL PHARMACOLOGY, 2008, 75 (04) :787-809