A-to-I editing: New and old sites, functions and speculations

被引：119

作者：

Seeburg, PH ^{[1
]}

机构：

[1] Max Planck Inst Med Res, Dept Mol Neurobiol, D-69120 Heidelberg, Germany

来源：

NEURON | 2002年 / 35卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(02)00760-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nuclear pre-mRNA editing by selective adenosine deamination (A-to-I editing) occurs in all organisms from C. elegans to humans. This rare posttranscriptional mechanism can alter codons and hence the structure and function of proteins. New findings report new sites, give evidence that the efficiency of editing can be regulated by neurotransmitter, and reveal that an amino acid substitution introduced by editing into a neurotransmitter-gated ion channel subunit serves as a determinant for controlling the maturation, intracellular trafficking, and assembly with other subunits of this transmembrane protein.

引用

页码：17 / 20

页数：4

共 18 条

[1] RNA editing by adenosine deaminases that act on RNA [J].

Bass, BL .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :817-846

[2] EARLY-ONSET EPILEPSY AND POSTNATAL LETHALITY ASSOCIATED WITH AN EDITING-DEFICIENT GLUR-B ALLELE IN MICE [J].

BRUSA, R ;

ZIMMERMANN, F ;

KOH, DS ;

FELDMEYER, D ;

GASS, P ;

SEEBURG, PH ;

SPRENGEL, R .

SCIENCE, 1995, 270 (5242) :1677-1680

[3]

Dingledine R, 1999, PHARMACOL REV, V51, P7

[4] Functions and mechanisms of RNA editing [J].

Gott, JM ;

Emeson, RB .

ANNUAL REVIEW OF GENETICS, 2000, 34 :499-U34

[5]

Grauso M, 2002, GENETICS, V160, P1519

[6] RNA editing at Arg607 controls AMPA receptor exit from the endoplasmic reticulum [J].

Greger, IH ;

Khatri, L ;

Ziff, EB .

NEURON, 2002, 34 (05) :759-772

[7] Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims [J].

Gurevich, I ;

Tamir, H ;

Arango, V ;

Dwork, AJ ;

Mann, JJ ;

Schmauss, C .

NEURON, 2002, 34 (03) :349-356

[8] Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2 [J].

Higuchi, M ;

Stefan, M ;

Single, FN ;

Hartner, J ;

Rozov, A ;

Burnashev, N ;

Feldmeyer, D ;

Sprengel, R ;

Seeburg, PH .

NATURE, 2000, 406 (6791) :78-81

[9] A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE [J].

HODGKIN, AL ;

HUXLEY, AF .

JOURNAL OF PHYSIOLOGY-LONDON, 1952, 117 (04) :500-544

[10] ASSEMBLY OF POTASSIUM CHANNELS [J].

LI, M ;

ISACOFF, E ;

JAN, YN ;

JAN, LY .

MOLECULAR BASIS OF ION CHANNELS AND RECEPTORS INVOLVED IN NERVE EXCITATION, SYNAPTIC TRANSMISSION AND MUSCLE CONTRACTION: IN MEMORY OF PROFESSOR SHOSAKU NUMA, 1993, 707 :51-59

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