A view into the catalytic pocket of cyclic nucleotide phosphodiesterases

被引：10

作者：

Conti, M ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Obstet & Gynecol, Div Reprod Biol, Stanford, CA 94305 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 09期

关键词：

D O I：

10.1038/nsmb0904-809

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic nucleotide phosphodiesterases are widely expressed enzymes that function as critical components of cell signaling pathways. In a new study, key interactions in the catalytic pocket essential for substrate selectivity have been identified for these enzymes, thus introducing novel perspectives for drug design.

引用

页码：809 / 810

页数：2

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