New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents

被引：63

作者：

Chimichi, S

Boccalini, M

Cosimelli, B

Viola, G

Vedaldi, D

Dall'Acqua, F

机构：

[1] Dipartimento Chim Organ U Schiff, I-50019 Florence, Italy

[2] Univ Bologna, Dipartimento Chim Organ A Mangini, I-40127 Bologna, Italy

[3] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 42期

关键词：

hydroxycoumarins coumarinyloxyaldehydes; geiparvarin analogues; muitumoral compounds;

D O I：

10.1016/S0040-4039(02)01798-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of compounds analogues of geiparvarin is described: aldolic condensation of 3(2H)-furanones and 7-(2-oxoethoxy)coumarins followed by a very efficient dehydration protocol led to the title compounds which show good antitumoral activity against several human cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：7473 / 7476

页数：4

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