Intravenous immunoglobulin: A safe option for treatment of steroid-resistant rejection in the presence of infection

被引：11

作者：

Moger, V ^{[1
]}

RaviShankar, MS ^{[1
]}

Sakhuja, V ^{[1
]}

Kohli, HS ^{[1
]}

Sud, K ^{[1
]}

Gupta, KL ^{[1
]}

Jha, V ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res, Dept Nephrol, Chandigarh 160012, India

来源：

TRANSPLANTATION | 2004年 / 77卷 / 09期

关键词：

D O I：

10.1097/01.TP.0000122415.08639.53

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Management of recurrent allograft rejection is a risky proposition, especially in the presence of infections. Both steroids and antibody therapy worsen the infection risk. We successfully treated steroid-resistant rejection with intravenous immunoglobulin (IVIG) in two patients who had concomitant infections. IVIG should be considered the treatment of choice for management of steroid-resistant rejection in the presence of serious infection.

引用

页码：1455 / 1456

页数：2

共 10 条

[1] Successful renal transplant outcome after intravenous gamma-globulin treatment of a highly sensitized pediatric recipient [J].

Al-Uzri, A ;

Seltz, B ;

Yorgin, PD ;

Spier, CM ;

Andreoni, K .

PEDIATRIC TRANSPLANTATION, 2002, 6 (02) :161-165

[2]

BUCKLEY RH, 1991, NEW ENGL J MED, V325, P110, DOI 10.1056/NEJM199107113250207

[3] A randomized and prospective study comparing treatment with high-dose intravenous immunoglobulin with monoclonal antibodies for rescue of kidney grafts with steroid-resistant rejection [J].

Casadei, DH ;

Rial, MD ;

Opelz, G ;

Golberg, JC ;

Argento, JA ;

Greco, G ;

Guardia, OE ;

Haas, E ;

Raimondi, EH .

TRANSPLANTATION, 2001, 71 (01) :53-58

[4]

Dwyer J M, 1987, Adv Intern Med, V32, P111

[5]

GUGLIELMO BJ, 1994, BONE MARROW TRANSPL, V13, P499

[6] Reversal of steroid- and anti-lymphocyte antibody-resistant rejection using intravenous immunoglobulin (IVIG) in renal transplant recipients [J].

Luke, PPW ;

Scantlebury, VP ;

Jordan, ML ;

Vivas, CA ;

Hakala, TR ;

Jain, A ;

Somani, A ;

Fedorek, S ;

Randhawa, P ;

Shapiro, R .

TRANSPLANTATION, 2001, 72 (03) :419-422

[7] HUMAN AUTOANTIBODIES REACTIVE WITH SYNTHETIC AUTOANTIGENS FROM T-CELL RECEPTOR BETA-CHAIN [J].

MARCHALONIS, JJ ;

KAYMAZ, H ;

DEDEOGLU, F ;

SCHLUTER, SF ;

YOCUM, DE ;

EDMUNDSON, AB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3325-3329

[8] Long-term benefit of intravenous immunoglobulins in cadaveric kidney retransplantation [J].

Peraldi, MN ;

Akposso, K ;

Haymann, JP ;

Flahaut, A ;

Marlin, C ;

Rondeau, E ;

Sraer, JD .

TRANSPLANTATION, 1996, 62 (11) :1670-1673

[9] Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection [J].

Rocha, PN ;

Butterly, DW ;

Greenberg, A ;

Reddan, DN ;

Tuttle-Newhall, J ;

Collins, BH ;

Kuo, PC ;

Reinsmoen, N ;

Fields, T ;

Howell, DN ;

Smith, SR .

TRANSPLANTATION, 2003, 75 (09) :1490-1495

[10] Acute renal failure in a renal allograft recipient treated with intravenous immunoglobulin [J].

Tsinalis, D ;

Dickenmann, M ;

Brunner, F ;

Gürke, L ;

Mihatsch, M ;

Nickeleit, V .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 40 (03) :667-670

← 1 →