Claudins - Key pieces in the tight junction puzzle

被引：78

作者：

Koval, Michael ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USA

来源：

CELL COMMUNICATION AND ADHESION | 2006年 / 13卷 / 03期

关键词：

occludin; ZO-1; PATJ; membrane microdomain; lipid raft; tetraspanins; EMP;

D O I：

10.1080/15419060600726209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Tight junctions restrict the flow of ions and aqueous molecules between cells by forming a selective barrier to the paracellular pathway. Permeability of the tight junction barrier is determined by a class of transmembrane proteins known as claudins. The relationship between claudins and paracellular permeability is complex and determined not only by the profile of claudin expression but also by the arrangement of claudins and other proteins into tight junction strands. This review summarizes progress in understanding how claudins are assembled into tight junctions and how they interact with other tight junction proteins.

引用

页码：127 / 138

页数：12

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