An Overview of MYC and Its Interactome

被引：317

作者：

Conacci-Sorrell, Maralice ^{[1
]}

McFerrin, Lisa ^{[1
]}

Eisenman, Robert N. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2014年 / 4卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HUMAN C-MYC; AVIAN MYELOCYTOMATOSIS VIRUS; TUMOR-SUPPRESSOR GENE; FBW7 UBIQUITIN LIGASE; RECRUITS P-TEFB; E-BOX SEQUENCES; DNA-BINDING; TRANSCRIPTIONAL REPRESSOR; CELL-CYCLE; HISTONE DEACETYLASE;

D O I：

10.1101/cshperspect.a014357

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.

引用

页数：24

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