Nakiterpiosin and nakiterpiosinone, novel cytotoxic C-nor-D-homosteroids from the Okinawan sponge Terpios hoshinota

被引：55

作者：

Teruya, T ^{[1
]}

Nakagawa, S ^{[1
]}

Koyama, T ^{[1
]}

Arimoto, H ^{[1
]}

Kita, M ^{[1
]}

Uemura, D ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Dept Chem, Nagoya, Aichi 4648602, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 33期

关键词：

C-nor-D-homosteroid; the sponge Terpios hoshinota; nakiterpiosin; nakiterpiosinone; cytotoxicity;

D O I：

10.1016/j.tet.2003.08.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cytotoxic compounds, nakiterpiosin (1) and nakiterpiosinone (2), were isolated from the Okinawan sponge Terpios hoshinota. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin (1) and nakiterpiosinone (2) showed potent cytotoxicity against mouse lymphocytic leukemia cell (P388). (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6989 / 6993

页数：5

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