Nuclear architecture and the induction of chromosomal aberrations

被引：110

作者：

Cremer, C

Munkel, C

Granzow, M

Jauch, A

Dietzel, S

Eils, R

Guan, XY

Meltzer, PS

Trent, JM

Langowski, J

Cremer, T

机构：

[1] UNIV HEIDELBERG, INTERDISZIPLINARES ZENTRUM WISSENSCH RECHEN, D-69120 HEIDELBERG, GERMANY

[2] DEUTSCH KREBSFORSCHUNGSZENTRUM, D-69120 HEIDELBERG, GERMANY

[3] UNIV HEIDELBERG, INST HUMAN GENET, D-69120 HEIDELBERG, GERMANY

[4] NIH, NATL CTR HUMAN GENOME RES, CANC GENET LAB, BETHESDA, MD 20892 USA

来源：

MUTATION RESEARCH-REVIEWS IN GENETIC TOXICOLOGY | 1996年 / 366卷 / 02期

关键词：

D O I：

10.1016/S0165-1110(96)90031-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Progress in fluorescence in situ hybridization, three dimensional microscopy and image analysis has provided the means to study the three-dimensional structure and distribution of chromosome territories within the cell nucleus. In this contribution, we summarize the present state of knowledge of the territorial organization of interphase chromosomes and their topological relationships with other macromolecular domains in the human cell nucleus, and present data from computer simulations of chromosome territory distributions. On this basis, we discuss models of chromosome territory and nuclear architecture and topological consequences for the formation of chromosome exchanges.

引用

页码：97 / 116

页数：20

共 81 条

[1] DIFFERENCES OF SIZE AND SHAPE OF ACTIVE AND INACTIVE X-CHROMOSOME DOMAINS IN HUMAN AMNIOTIC-FLUID CELL-NUCLEI [J].