Modulation of natural killer cell activity affected by electroacupuncture through lateral hypothalamic area in rats

被引：27

作者：

Choi, GS

Oh, SD

Han, JB

Bae, HS

Cho, YW

Yun, YS

Lee, WK

Ahn, HJ

Min, BI ^{[1
]}

机构：

[1] Kyung Hee Univ, Grad Sch, Dept E W Med, Seoul, South Korea

[2] Kyung Hee Univ, Coll Med, Dept Microbiol, Seoul, South Korea

[3] Gachon Med Coll, Dept Anat, Inchon, South Korea

[4] Korea Canc Ctr Hosp, Immunol Lab, Seoul, South Korea

[5] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul, South Korea

[6] Kyung Hee Univ, Coll Oriental Med, Dept Physiol, Dongdaemun Gu, Seoul 130701, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 329卷 / 01期

关键词：

electroacupuncture; lateral hypothalamic area; natural killer cell activity;

D O I：

10.1016/S0304-3940(02)00551-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Electroacupuncture (EA) has been reported to modulate natural killer cell (NK cell) activities. Also it is well known that hypothalamus directly mediates the effects of EA on analgesia. Especially lateral hypothalamic area (LHA) is related to splenic INK cell activities. In order to investigate the relationship between hypothalamus and effects of EA on NK cell activity, lesions have been made bilaterally at LHA of Spraque-Dawley rats. Subsequently, NK cell cytotoxities of normal and lesioned rats were measured with Cr-51 release immunoassay after EA stimulation for 2 and 14 days. NK cell activity of EA group was significantly higher than sham group. In addition, lesions abolished effects of EA on INK cell activity. These results strongly suggest that LHA is closely related to increase of NK cell activity induced by EA. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

共 16 条

[1] NEONATAL SYMPATHETIC DENERVATION ALTERS THE DEVELOPMENT OF INVITRO SPLEEN-CELL PROLIFERATION AND DIFFERENTIATION [J].