Essential role for collectrin in renal amino acid transport

被引:186
作者
Danilczyk, Ursula
Sarao, Renu
Remy, Christine
Benabbas, Chahira
Stange, Gerti
Richter, Andreas
Arya, Sudha
Pospisilik, J. Andrew
Singer, Dustin
Camargo, Simone M. R.
Makrides, Victoria
Ramadan, Tamara
Verrey, Francois
Wagner, Carsten A.
Penninger, Josef M.
机构
[1] Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria
[2] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland
[3] Univ Zurich, Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland
[4] Univ Vienna, Ctr Ecol, Dept chem Ecol & Ecosyst Res, A-1090 Vienna, Austria
[5] Hosp Sick Children, Toronto, ON M5G 1X8, Canada
关键词
D O I
10.1038/nature05475
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Angiotensin-converting enzyme 2 (ACE2) is a regulator of the renin angiotensin system involved in acute lung failure, cardiovascular functions and severe acute respiratory syndrome (SARS) infections in mammals(1-3). A gene encoding a homologue to ACE2, termed collectrin (Tmem27), has been identified in immediate proximity to the ace2 locus(4). The in vivo function of collectrin was unclear. Here we report that targeted disruption of collectrin in mice results in a severe defect in renal amino acid uptake owing to downregulation of apical amino acid transporters in the kidney. Collectrin associates with multiple apical transporters and defines a novel group of renal amino acid transporters. Expression of collectrin in Xenopus oocytes and Madin-Darby canine kidney (MDCK) cells enhances amino acid transport by the transporter B-0 AT1. These data identify collectrin as a key regulator of renal amino acid uptake.
引用
收藏
页码:1088 / 1091
页数:4
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